MED­I­CAL FRONT

EQUUS - - Contents -

Ge­netic dis­or­der in Arabians in­ves­ti­gated Han­dle equine oral tissues with care

Pos­i­tive prog­no­sis for one type of poll in­jury An­tivi­ral drug shows prom­ise against EHV-1

New re­search shows that ju­ve­nile id­io­pathic epilepsy (JIE) is not ge­net­i­cally re­lated to laven­der foal syn­drome (LFS), se­vere com­bined im­mun­od­e­fi­ciency (SCID) or other pre­vi­ously iden­ti­fied in­her­ited con­di­tions af­fect­ing the Ara­bian breed.

JIE, which is typ­i­cally seen in Ara­bian foals be­tween 2 days and 6 months of age, is char­ac­ter­ized by “tonic/ clonic” seizures that start with body-wide mus­cle stiff­ness and cul­mi­nate in re­cum­bency, rapid mus­cle con­trac­ture and loss of con­scious­ness.

Foals can in­jure them­selves dur­ing seizures, which may last a few sec­onds or sev­eral min­utes. Seizures are fol­lowed by tem­po­rary blind­ness and/or dis­ori­en­ta­tion. Some foals suc­cumb to seizure-re­lated prob­lems, but most out­grow JIE within a year or 18 months.

JIE is an in­her­ited epilep­tic dis­or­der, so re­searchers at the Univer­sity of Cal­i­for­nia–Davis sought to de­ter­mine whether it is as­so­ci­ated with other ge­netic con­di­tions found in Arabians. The re­searchers an­a­lyzed the DNA of 10 foals di­ag­nosed with JIE to look for the mu­ta­tions that cause LFS, SCID, cere­bel­lar abiotro­phy (CA) and oc­cip­i­toat­lantoax­ial mal­for­ma­tion (OAAM1). They found that the JIE foals did not have mu­ta­tions for any of those con­di­tions and, there­fore, con­cluded there is no as­so­ci­a­tion be­tween them.

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