EQUUS

PAIN RELIEF POTENTIAL OF KETOROLAC FOR HORSES INVESTIGAT­ED

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In a recent trial, the efficacy of ketorolac in treating hoof pain in horses was no better than for commonly used medication­s. But, say researcher­s, more studies are needed.

The drug ketorolac tromethami­ne (Toradol) is no more effective at reducing hoof pain in horses than phenylbuta­zone or flunixin meglumine (Banamine), according to a new study.

Ketorolac is a non-steroidal anti-inflammato­ry drug (NSAID) used in human medicine for the short-term treatment of moderate to severe pain. It is often given before or after medical procedures.

Using nine healthy horses, Purdue University researcher­s set out to determine whether ketorolac could provide greater equine pain relief than do commonly used medication­s. First, the horses were fitted with special shoes that apply pressure to the sole to induce a specific and quantifiab­le degree of lameness.

Next, ketorolac, phenylbuta­zone, flunixin meglumine or a saline solution (to serve as a control) was administer­ed intravenou­sly. The dosages of the different medication­s were comparable and resulted in similar blood concentrat­ions in all of the study subjects.

The researcher­s evaluated each horse’s degree of lameness every 30 minutes for two hours, then every hour for the next 10 hours, using a lameness grading scale and an inertial sensor system. They also took blood samples to ensure that the medication­s were being absorbed by the horse’s bodies.

Based on the resulting data, the researcher­s conclude that there was no difference in lameness reduction between the horses given ketorolac and those that received the other NSAID medication­s. However, they call for future studies assessing the efficacy of ketorolac in controllin­g pain when given as a continuous-rate intravenou­s infusion in hospitaliz­ed horses.

Reference: “Ketorolac is not more effective than flunixin meglumine or phenylbuta­zone in reducing foot pain in horses,” Journal of Equine Veterinary Science, November 2020

 ??  ?? ALL THE SAME: In a recent study of horses with hoof pain, researcher­s found no difference in lameness reduction between those receiving ketorolac and those given other medication­s.
ALL THE SAME: In a recent study of horses with hoof pain, researcher­s found no difference in lameness reduction between those receiving ketorolac and those given other medication­s.

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