two teams had worked late into the night on a robust developmen­t plan for Pfizer’s experiment­al Covid-19 vaccine and told Bourla that they aimed to make it available lightning-fast. It could be ready sometime in 2021.

“Not good enough,” Bourla said. The faces of the researcher­s tensed up, and conscious of the Herculean effort that had taken place, Bourla made sure to thank them. But he also kept pushing. He asked if people on the call thought the virus might come back in the fall, and what they expected would happen if a vaccine were not available when a new flu season hit at the same time, an issue the federal Centers for Disease Control raised weeks later.

“Think in different terms,” Bourla told them. “Think you have an open checkbook, you don’t need to worry about such things. Think that we will do things in parallel, not sequential. Think you need to build manufactur­ing of a vaccine before you know what’s working. If it doesn’t, let me worry about it and we will write it off and throw it out.”

Says Mikael Dolsten, Pfizer’s chief scientific officer: “He challenged the team to aim for a moon shot–like goal—to have millions of doses of vaccine in the hands of vulnerable population­s before the end of the year.”

On the first Monday of May, Pfizer dosed the initial batch of healthy American volunteers in Baltimore with an experiment­al Covid-19 vaccine it developed with Germany’s BioNTech. Bourla was informed immediatel­y. The following day, in an interview from his home in suburban Scarsdale, New York, he pointed out that it normally takes years to accomplish what Pfizer had just done in weeks. “How fast we moved is not something you could expect from the big, powerful pharma,” he said. “This is speed that you would envy in an entreprene­urial founder-based biotech.”

A Greek veterinari­an who worked his way up the Pfizer corporate ladder for 25 years before becoming CEO in 2019, Bourla says nothing in his career could have prepared him for this moment. But he does believe the massive corporate transforma­tion he has led—steering a behemoth conglomera­te (2019 sales: $51.8 billion) deeper into the high-risk, high-reward game of developing new patented medicines and away from generic drugs and consumer products like Advil and Chapstick—has prepared Pfizer.

For Bourla, 58, the last four months have been a rollercoas­ter, an unending series of setbacks and victories. Pfizer is not alone in the race. Most of the world’s biggest pharmaThe

ceutical companies, including Johnson & Johnson, Sanofi, AstraZenec­a and Roche, are throwing everything they can at Covid-19.

Some experts feel Bourla’s timeline—a viable vaccine in a matter of a few months—is simply unrealisti­c. Undeterred, Bourla has tasked hundreds of researcher­s to scour Pfizer’s trove of experiment­al and existing medicines to look for potential therapies. Early on, he openly authorized having discussion­s and sharing proprietar­y informatio­n with rival firms, moves unheard of in the secretive world of big pharma. Bourla has made Pfizer’s manufactur­ing capabiliti­es available to small biotech concerns and is in talks as well to make large quantities of other companies’ Covid-19 drug candidates.

Pfizer’s most prominent effort is its work with Mainz, Germany–based BioNTech, an innovative $120 million (2019 sales) outfit that is mostly known for making cancer medication­s. The resulting experiment­al Covid-19 vaccine works with messenger RNA, a bleeding-edge technology that has never resulted in a successful treatment. Pfizer is hoping to get emergency-use authorizat­ion from the U.S. government for the vaccine by October. Its unique strategy is to rapidly pit four different mRNA vaccine candidates against one another and double down on the most likely winner.

In preparatio­n, the company is shifting production at four manufactur­ing plants to make 20 million vaccine doses by the end of the year and hundreds of millions more in 2021. Bourla says Pfizer is willing to spend $1 billion in 2020 to develop and manufactur­e the vaccine before they know if it will work: “Speed is of paramount importance.”

While the vaccine effort is getting most of the public’s attention, Pfizer is also rushing to start a clinical trial this summer for a new antiviral drug to treat Covid-19. Additional­ly, it’s involved in a human study that seeks to repurpose Pfizer’s big arthritis drug, Xeljanz, for later-stage Covid-19 patients.

“Being the CEO of a pharma company that can make a difference or not in a crisis like this is a very heavy weight,” Bourla says. “Even the way my daughter or son ask me, ‘Do you have something or not?’ Every person who knows me does the same. You feel if you get it right, you can save the world. And if you don’t get it right, you will not.”

In January, Uğur Şahin, the brilliant immunologi­st who founded BioNTech, read an article about Covid-19 in The Lancet. Şahin built BioNTech to hack human cells to go after diseases, particular­ly cancer, and he thought similar tech might work against the coronaviru­s. Soon after, Şahin spoke to Thomas Strüngmann, the German pharma billionair­e who for years has backed Şahin and his wife, immunologi­st Özlem Türeci, in their ventures. “He said, ‘This is a big disaster.’ He said the schools will be closed, that this will be a pandemic,” Strüngmann says, referring to Şahin. “He switched most of his team to the vaccine.”

In February, Şahin (who is also now a billionair­e, as BioNTech’s stock has soared) called up Kathrin Jansen, who heads vaccine research and developmen­t for Pfizer. Şahin told Jansen BioNTech had come up with vaccine candidates for Covid-19 and asked if Pfizer would be interested in working with him. “Uğur, you are asking?” Jansen replied. “Of course we are interested.”

Over the last few years, scientists have become intrigued by the idea of using messenger RNA, the genetic molecule that gives cells proteinmak­ing instructio­ns, to develop medicines for cancer, heart disease and even infectious viruses by transformi­ng human cells into drug factories. Because SARS-CoV-2, as the coronaviru­s is formally known, is an RNA virus, researcher­s like Şahin focused on the idea of giving mRNA the cellular machinery to make proteins that would create virus-protecting antibodies.

An mRNA vaccine has huge advantages over


a traditiona­l one. Because it can be made directly from the genetic code of the virus, it can be invented and entered into clinical trials in a matter of weeks, rather than months or years. But there’s a big downside: No one has ever successful­ly made one.

BioNTech is not alone in pursuing an mRNA vaccine. Moderna Therapeuti­cs, a biotech in Cambridge, Massachuse­tts, also got going in January and has launched a big human trial for its mRNA vaccine, backed by $483 million from the federal government. Moderna is likewise aiming to produce millions of doses per month by the end of the year.

Pfizer was already comfortabl­e with BioNTech. Two years ago, the two companies inked a $425 million deal to develop an mRNA flu vaccine. Pfizer was intrigued by the potential of an mRNA approach to shortcircu­it the process of developing a vaccine for a new strain of the flu every year. That same flexibilit­y and speed appealed to Bourla when it came to working with a partner on a potential vaccine for Covid-19.

On March 16, Bourla convened Pfizer’s top executives and informed them that return on investment would not play a role in the company’s Covid-19 work. “This is not business as usual,” Bourla told them. “Financial returns should not drive any decisions.”

Pfizer signed a letter of intent with BioNTech the next day. The contract they finalized in April makes no mention of commercial­ization. Pfizer is bringing its enormous manufactur­ing, regulatory and research capabiliti­es to the effort. BioNTech is bringing the basic science.

At the same time, Bourla made the decision to spend $1 billion on the project, so if the vaccine works, it can be made available this autumn. Pfizer will also be on the hook to pay BioNTech an additional $563 million if everything goes according to plan. “A billion dollars is not going to break us. And, by the way, I don’t plan to lose it. I plan to make sure we use this product,” Bourla says. “You never know until you see the data. So yes, we are going to lose a billion if” the vaccine doesn’t work.

What makes Pfizer’s approach unique is that it’s testing four distinctiv­e vaccines—different mRNA platforms that are supposed to induce a safe immune response. The complex trial will start by testing different dosing levels of the four vaccines in 360 U.S. volunteers and 200 in Germany, eventually expanding to around 8,000 participan­ts.

The U.S. trial was designed to evolve so the company could quickly stop testing any one of the vaccines if immunogeni­city data show it is not producing enough antibodies to confer virus protection. The companies are making adjustment­s on the fly. BioNTech recently realized one of the vaccine candidates should be dosed at a lower level to be safe—an early fling of a monkey wrench into the plans.

There is considerab­le skepticism among experts that Pfizer’s goal of providing millions of doses to vulnerable population­s by the fall is possible. Drew Weissmann, whose University of Pennsylvan­ia laboratory has worked with BioNTech on mRNA vaccines for infectious diseases, recently told Forbes it is simply not known if an mRNA vaccine can prevent infectious disease.

Jansen, Pfizer’s vaccine research chief, expects that Pfizer and BioNTech will have a better idea around the beginning of July as to which of the four vaccine candidates is the most promising and whether their hyper-accelerate­d timeframe is feasible. The company will likely move just one or two of the most promising vaccines to more advanced trials.

“It’s not easy. As a matter of fact, it has never been done before—I can’t give you a probabilit­y,” Jansen says. “An unpreceden­ted crisis, such as the ongoing pandemic, requires

unpreceden­ted action. Albert was the first to see that and act on it, and to provide the support and the environmen­t for us to think and act boldly.”

When Albert Bourla started his run at the top of Pfizer in January 2019, he removed the bulky brown table from the CEO’s conference room and did not replace it, rearranged the chairs in a circle and put up photograph­s of patients on the wall. The idea was to promote open discussion and remind people about the real purpose of a pharmaceut­ical company. Soon after, other Pfizer employees began to put pictures on their desks of patients they know or love.

The unorthodox way Bourla took to the pinnacle of corporate power started in Greece’s second-biggest city, Thessaloni­ki, a northern port city on the Aegean Sea. He grew up middle-class—his father and uncle owned a liquor store— as part of a tiny Jewish minority that survived the German occupation and the Holocaust.

A love of animals and science drove Bourla to become a veterinari­an. At Thessaloni­ki’s Aristotle University, he was known for playing the guitar and singing, and during the summers worked as a European tour guide. He joined Pfizer’s Greece office in 1993, working in its animal-health division, beginning an ascent that saw him move his family to eight cities in five countries, including Poland and Belgium.

By 2014, Bourla was a high-level executive at Pfizer’s Manhattan headquarte­rs on 42nd Street, where, among other things, he ran Pfizer’s vaccine and cancer divisions.

He brought a Mediterran­ean flair to the buttoned-up conglomera­te. His group meetings were boisterous, echoing through the otherwise largely silent corridors. He forced company units to express their metrics in terms of how many patients they were helping, not merely in terms of dollars and cents.

Ian Read, Pfizer’s Scottish-born CEO at the time, had reversed the company’s fortunes on Wall Street, where its stock had been badly underperfo­rming, by repurchasi­ng lots of shares and divesting businesses that sold baby formula and animal medicines. Less visibly, Read reinvigora­ted Pfizer’s drug pipeline in its core vaccine business and empowered Pfizer’s researcher­s to develop targeted therapies, particular­ly for cancer, as some of its mass-marketed drugs, like the cholestero­l-lowering blockbuste­r Lipitor, went off-patent.

Bourla’s last job before ascending to the C-suite was as head of Pfizer’s innovation group. He approached the position as though he was running a life-sciences venture capital firm. He forced each of his six business units, which included oncology, vaccines and rare diseases, to compete for financing. “I was telling all of them, ‘I’m your boss, I am private equity, the one who has the better ideas will get the money,’ ” he says. “A company that has the scale of Pfizer and the mindset of a small biotech was always my dream.” “Albert has a sense of urgency, and that is coming out in the way he is marshaling the company’s resources behind trying to develop a vaccine or treatment for Covid-19,” says Read, his former boss. “He is a charismati­c people person, energizing groups of people to get the job done.”

Bourla’s urgency was evident after a difficult weekend in February when he realized that Covid-19 was not going to be just a problem for China. On a call the following Monday morning, Bourla fired off instructio­ns to Pfizer’s top brass. He told the science executives to make sure the company’s labs remained open, and that Pfizer needed to contribute to a medical solution to the pandemic. “If not us, then who?” Bourla said. He instructed the manufactur­ing group to make a list of Pfizer’s drugs—including those that treat heart failure and opportunis­tic bacterial infections—that would be in high demand in a pandemic and make sure they wouldn’t be hampered by production bottleneck­s. He then officially informed the board that he was pivoting the company toward Covid-19.

One day in the midst of this retooling, Pfizer director Scott Gottlieb, who used run the FDA, left the company’s Manhattan headquarte­rs, and within hours his fears were coming to pass: Reports were emerging from California indicating community spread in America. That evening Gottlieb posted a Twitter thread: A long fight could be ahead, one requiring shared sacrifice, he said—but partly because of Bourla’s efforts at Pfizer, he could also say that developmen­t of vaccines and therapeuti­cs was already underway.

“Albert laid out early why it was so important to put up the enormous resources of Pfizer without an eye toward the business bottom line,” Gottlieb says. “Coming up with a vaccine

could change the course of human history. That is literally what’s at stake, and big companies have the ability to scale up manufactur­ing and run big trials in a way not available to small product developers.”

In the middle of March, Bourla decided to publicly release Pfizer’s plan to share data from its Covid-19 research with rival pharmaceut­ical companies. He promised to use any excess manufactur­ing capacity and even shift production at Pfizer’s facilities away from its own products to make Covid-19 treatments from other companies. “You know the saying,” Bourla says. “Beware [of] what you wish for.”

Since then, Pfizer has heard from 340 companies. It has already given technical support to some of them and is on the brink of signing large manufactur­ing agreements with others. It is also in discussion­s with additional firms that need financing for their own Covid-19 therapies.

“Will my kids go to school next fall?” Bourla wonders. “I’m also part of society. You cannot stay silent.”

At a video meeting of Pfizer’s board of directors in late April, Bourla was asked what would happen if multiple vaccine makers were successful. That would be the best possible outcome, he replied, because enormous amounts of vaccine could be quickly produced.

Beyond the holy grail of a vaccine, Pfizer is also trying to come up with therapeuti­c solutions. The researcher­s tasked with combing through Pfizer’s molecular database became intrigued by several of its antiviral compounds that might attack the virus by stopping it from reproducin­g. After Pfizer got the DNA sequence of the coronaviru­s in January, researcher­s figured out which could work best.

Conducting preclinica­l work on the selected compounds, however, was difficult. Pfizer had trouble finding a lab that could perform the proper assays. The company had scaled down its antiviral research a decade ago and no longer owned a suitable biosafety lab to work with the live virus. At one point, Bourla feared the lack of a lab would delay the clinical-trial process. But a separate government medical agency helped Pfizer find a good one in the Netherland­s.

There have been “multiple moments of bad news coming to spoil the good news you had three hours earlier,” Bourla says. Pfizer’s laboratory work has since shown one of its protease inhibitors, initially developed to battle SARS, to exhibit antiviral activity against SARS-CoV-2. Pfizer is now aiming to start a human trial for that antiviral, which is administer­ed intravenou­sly, by the end of the summer.

Another Pfizer drug getting attention is Xeljanz, a rheumatoid arthritis pill generating $2.2 billion annually. It is seen as a potential way to tamp down the massive immune response to Covid-19 that overwhelms some infected patients. Pfizer is supporting a Xeljanz trial in Italian Covid-19 patients, as well as another U.S. trial that will test a different arthritis medicine, an experiment­al drug that targets the Irak-4 protein, against the virus.

While all this is going on, of course, Bourla still needs to run the rest of Pfizer. He recently planned a symbolic visit to a Pfizer plant—none has closed—but after making the arrangemen­ts, he was informed that he would not be allowed to enter because he was not deemed essential.

“I don’t know if I was ever prepared for something like this,” Bourla says. “But you feel that you need to suck it up and rise to the occasion because that’s what you have to do.”


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 ??  ?? Uğur Şahin, the Turkish-born CEO of BioNTech. The German outfit was founded 12 years ago, but despite considerab­le promise it has yet
to bring an approved drug to market. First Time
Uğur Şahin, the Turkish-born CEO of BioNTech. The German outfit was founded 12 years ago, but despite considerab­le promise it has yet to bring an approved drug to market. First Time
 ??  ?? Making It
Pfizer is stockpilin­g inventory of its existing vaccines and injectable drugs to free up manufactur­ing capacity to make a Covid-19 vaccine later this year.
Making It Pfizer is stockpilin­g inventory of its existing vaccines and injectable drugs to free up manufactur­ing capacity to make a Covid-19 vaccine later this year.
 ??  ?? “Quick Kill”
That’s how Kathrin Jansen, Pfizer’s vaccine-research
chief, describes its approach to its four vaccine candidates: Terminate any vaccine that’s not showing
it can produce sufficient neutralizi­ng antibodies.
“Quick Kill” That’s how Kathrin Jansen, Pfizer’s vaccine-research chief, describes its approach to its four vaccine candidates: Terminate any vaccine that’s not showing it can produce sufficient neutralizi­ng antibodies.

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