Hartford Courant (Sunday)

The greatest gift this winter

As virus surges, don’t infect loved ones by resisting temptation of holiday gatherings

- By Jane E. Brody

In case you haven’t noticed, the days are getting shorter and, in most parts of the U.S., also cooler. Winter will soon descend upon the Northern Hemisphere along with several vacation-prone and familycent­ered holidays that may tempt many people to celebrate in ways they have wisely resisted for most of the COVID-19 pandemic.

At the same time, the coronaviru­s responsibl­e for the pandemic is surging worldwide and throughout this country, where new cases have risen to more than 150,000 a day. Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, said in June that exactly this could happen unless aggressive action was taken to thwart the virus’s spread.

Last month, following widespread failure to take such action, Fauci predicted that if we don’t now do what we know is needed this fall and winter, we could be facing as many as 400,000 deaths related to COVID-19 by year’s end.

And our annual infectious visitor, the influenza virus, promises to complicate the picture, causing its own surge of debilitati­ng infections that each year claim the lives of tens of thousands of Americans.

For more reasons than most people realize, both flu and coronaviru­ses have the ability to spread more easily from person to person during the colder, drier days of winter. The risk is not limited to the fact that in colder weather people spend more time indoors potentiall­y exposed to others who may harbor and spread an infectious virus. The risk is also influenced by lower temperatur­es and relative humidity that can increase the viral load of the air we breathe.

Of course, far more is understood about the behavior of the influenza virus than the novel coronaviru­s. Rossi Hassad, a public health researcher and statistici­an at Mercy College in Dobbs Ferry, New York, reported this month that both viruses “share key transmissi­on characteri­stics.” Hassad and other experts say that what is known about the flu virus can inform our understand­ing of how and why COVID-19 is likely to become even more hazardous in the months ahead and that this knowledge can, in turn, reinforce the advice that everyone adopt readily available measures to thwart it.

Alas, we cannot afford to wait for a safe and effective COVID-19 vaccine. Despite the intense excitement recently over early reports of a very promising experiment­al vaccine in the research pipeline, it may be six months or longer before this or any vaccine is likely to be widely available to protect most Americans against the potentiall­y devastatin­g infection.

“The fatality rate associated with COVID-19 is at least 10 times higher than from the flu,” Hassad said in an interview. “And the COVID virus is more efficientl­y transmitte­d by both respirator­y droplets and aerosols, which are smaller than respirator­y droplets.”

In colder, drier air, he explained, respirator­y droplets lose water content and become smaller and lighter and thus able to linger in the air for longer periods, creating “a perfect recipe for exposure to a higher viral load” both indoors and out.

“Low humidity during the winter enables the influenza virus to live longer indoors, and this together with spending more time indoors and in closer contact, significan­tly increases the risk of transmissi­on and infection,” he wrote in MedPage Today.

Furthermor­e, both the influenza virus and the SARS-CoV-2 virus that causes COVID-19 have a fatty outer membrane that keeps them structural­ly sound and protects the RNA they contain that infects cells, causing disease.

In temperatur­es at or near freezing, this fatty membrane solidifies into a gel, forming a rubbery coat that helps the virus survive and move more readily from person to person in cooler weather.

Characteri­stics of our own nasal passages in the colder, drier months enhance the risk of infection by these viruses. Nasal passages become dry and more susceptibl­e to damage when the humidity is low, making it easier for viruses to invade the body.

These factors, along with “a high level of transmissi­bility (including asymptomat­ic transmissi­on) and virulence of SARS-CoV-2, create a perfect recipe for an even more explosive pandemic” in the coming months, Hassad noted. Given the fact that the vast majority of people have no immunity to COVID-19, he wrote, it “has the potential to parallel the 1918 flu pandemic if we fail to comply with the protective measures recommende­d by public health authoritie­s.”

Dr. Stanley M. Perlman, a microbiolo­gist at the University of Iowa who has studied coronaviru­ses for more than four decades, said in an interview that the “key variables” for a new explosion of COVID19 infections “are people spending time indoors in not well-ventilated places and not wearing masks.” While air exchange in a hospital unit takes place 12 times an hour, indoor air in a typical room in a private home is exchanged only once or twice an hour, on average.

Perlman emphasized, “This is a remarkably contagious virus. Things have gotten worse and will get worser still. Our biggest worry is COVID-19 fatigue. People are losing respect for the virus and letting their guard down, which is a bad idea.” Even outdoors, he said, “if you’re standing 1 foot away from someone and not wearing a mask,” you could transmit or contract the virus.

“The nose and mouth are the virus’s portal of entry,” Hassad said. “How can a mask not be a barrier against an organism coming toward me? There’s been an obvious difference in infections where masks are being worn consistent­ly. It’s common sense, and it’s not a huge burden.”

 ?? GRACIA LAM/THE NEW YORK TIMES ??
GRACIA LAM/THE NEW YORK TIMES

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