Hartford Courant (Sunday)

Interestin­g facts about Alzheimer’s diseases

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Of the roughly 55 million people around the world living with dementia, 60 to 70 percent are estimated to have Alzheimer’s disease, reports the Mayo Clinic.

Alzheimer’s disease is a progressiv­e brain disorder marked first by mild memory loss that can worsen and lead to problems with communicat­ion and an inability to perform the activities of daily life. The condition is named for

Dr. Alois Alzheimer. In 1906, Alzheimer noticed changes in the postmortem brain tissue of a woman who had died of unusual mental illness, which included symptoms of language problems, memory loss and unpredicta­ble behavior. Her brain showed many abnormal clumps and tangled bundles of fibers. According to the National Institute on Aging, doctors now know those clumps are amyloid plaques and the tangles are hallmarks of the disease.

The National Institutes of Health says Alzheimer’s disease is the seventh leading cause of death in the United States and is the most common dementia among older adults. While most people are familiar with Alzheimer’s, there is much more anyone can learn. The following are some interestin­g facts about Alzheimer’s.

• The most common symptoms of Alzheimer’s involve a gradual decline in memory, reasoning, language, coordinati­on, mood, and behavior.

• The Cleveland Clinic says the buildup of plaques and tangles from an overabunda­nce of amyloid and tau protein production block the communicat­ion between nerve cells and cause brain cells to die, thus contributi­ng to Alzheimer’s. Nerve cell death starts in the hippocampu­s, the area of the brain that controls memory. Doctors are not entirely sure what causes this protein build-up.

• Many times family members are the first to recognize a friend or loved one forgetting newly learned informatio­n, especially recent events, places and names.

• Issues with thinking and reasoning may include not wearing the right clothes for the weather or not knowing to use oven mitts when taking hot items out of the oven.

• Changes in the brain can begin years before initial symptoms appear, according to the Centers for Disease Control and Prevention. Age is the biggest risk factor for Alzheimer’s. Researcher­s believe that genetics may play a role, but a genetic predisposi­tion to Alzheimer’s does not make it an inevitabil­ity.

• A healthy lifestyle, which includes adequate physical activity, a nutritious diet, limited alcohol consumptio­n, and not smoking, may help people avoid Alzheimer’s.

• Alzheimer’s can rob a person of his or her personalit­y. As the disease becomes more severe, mood swings, anger, depression, and anxiety may occur. This is combined with the patient forgetting who family members are and potentiall­y lashing out or being disinteres­ted in visitors.

• There is no cure for Alzheimer’s, but doctors use medical management to improve quality of life for patients and their caregivers. Treatments may help maintain brain health and manage behavioral symptoms.

Alzheimer’s disease was first diagnosed at the start of the 20th century. Now, 117 years later, it remains a major health issue affecting millions of people worldwide.

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