Houston Chronicle Sunday

Origin of virus is likely to remain murky

- By Julian E. Barnes

WASHINGTON — U.S. intelligen­ce agencies are unlikely to be able to draw a firm conclusion about the origin of the novel coronaviru­s without more informatio­n from China on the earliest cases or new scientific discoverie­s about the nature of the virus, a newly declassifi­ed intelligen­ce report released Friday said.

President Joe Biden ordered the nation’s intelligen­ce agencies in May to conduct a 90-day inquiry into the origins of the pandemic. When the key findings of that review were released in August, they failed to offer a single answer and instead reaffirmed the longstandi­ng position of the agencies: the theory that the virus occurred naturally and the theory that it was accidental­ly created in a lab were both plausible.

But the report Friday reiterated that the evidence to support either conclusion was thin and that U.S. intelligen­ce agencies know far too little about the origin of the virus. The intelligen­ce community has concluded that the virus was not developed as a biological weapon.

Analysts “assess that a natural origin and a laboratory-associated incident are both plausible hypotheses for how SARS-CoV-2 first infected humans,” the report said. “Analysts, however, disagree on which is more likely, or whether an assessment can be made at all.”

Four intelligen­ce agencies and the National Intelligen­ce Council consider the natural causes theory more plausible. One agency, the FBI, backs the lab leak theory. But none of those agencies has delivered to the director of national intelligen­ce or the White House a high-confidence assessment, which shows the doubt that continues to swirl around the question.

The intelligen­ce community has broadly concluded that the virus causing COVID-19 was not deliberate­ly engineered in a lab. But even that conclusion is made only with low confidence. Some genetic engineerin­g techniques make modificati­ons difficult to identify, particular­ly given existing gaps in knowledge about the diversity of naturally occurring coronaviru­ses.

“Some genetic engineerin­g techniques may make geneticall­y modified viruses indistingu­ishable from natural viruses, according to academic journal articles,” the report said.

The intelligen­ce report said the Wuhan Institute of Virology in China had previously made chimeras, or combinatio­ns of coronaviru­s that did not occur in nature. But that record provides little insight on whether the virus that causes COVID-19 was geneticall­y engineered, the report said.

Some Republican lawmakers have seized on that so-called gain-of-function work at the institute, arguing it buttresses the lab leak theory. At a House Intelligen­ce Committee hearing this week, Rep. Brad Wenstrup, R-Ohio, a medical doctor, called for more examinatio­n of the institute’s work on creating chimeras.

“In this case, that means experiment­ally combining components from two viruses into one for the sake of making it more infectious to the general public,” said Wenstrup, who has called for more hearings on the origin of the pandemic. “I can’t be sure that COVID-19 originated from a research-related accident or infection from a sampling trip, but I’m 100 percent sure there was a massive cover-up.”

The National Institutes of Health has said the chimera experiment­s in Wuhan were based on coronaviru­ses that were not the progenitor­s of the virus that causes COVID-19.

There is broad agreement in the Biden administra­tion that China has not shared all it can about the origins of the outbreak. The intelligen­ce report released Friday called for more transparen­cy by China, and it said Beijing needed to release informatio­n about possible intermedia­te species that the virus could have infected before leaping to humans; what it knows about the nature of the first human infections; and more data about the Wuhan Institute of Virology’s research work.

But the report also made clear that on some matters, Chinese officials were initially caught off-guard. Critically, U.S. intelligen­ce analysts have assessed that Chinese officials did not know about the existence of the novel coronaviru­s until after COVID-19 was detected in the population and it was isolated by the Wuhan institute.

“Accordingl­y, if the pandemic originated from a laboratory-associated incident, they probably were unaware in the initial months that such an incident had occurred,” the report said.

The report also suggested that the Wuhan institute researcher­s were not aware of the virus until the outbreak was underway, since they quickly pivoted to working on COVID-19 as the outbreak grew worse. The new report relied on the apparent surprise of Chinese officials and the Wuhan institute’s researcher­s as the pandemic grew worse to buttress the natural causes theory.

The wide array of animals susceptibl­e to the virus causing COVID-19, and the various ways humans in China come in contact with those animals — including traffickin­g, farming, sale and rescue — make natural transmissi­on possible.

While no animal source has been found, “analysts that assess the pandemic was due to natural causes note that in many previous zoonotic outbreaks, the identifica­tion of animal sources has taken years, and in some cases, animal sources have not been identified,” the report said.

On the flip side, analysts who supported the lab leak theory have also not found a smoking gun. Instead, they have highlighte­d that previous coronaviru­s work at the Wuhan institute was conducted under “inadequate biosafety conditions that could have led to opportunit­ies for a laboratory-associated incident.”

 ?? New York Times file photo ?? Paramedics transport a patient believed to be Hong Kong’s first coronaviru­s patient to a hospital on Jan. 22, 2020.
New York Times file photo Paramedics transport a patient believed to be Hong Kong’s first coronaviru­s patient to a hospital on Jan. 22, 2020.

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