Houston Chronicle Sunday

Another booster shot might be coming soon

- By Rong-Gong Lin II, Luke Money and Sean Greene

LOS ANGELES — As government officials close the book on the emergency phase of the COVID-19 pandemic, health authoritie­s are turning their attention to the next chapter of the vaccinatio­n campaign.

Though nothing is etched in stone, federal officials are considerin­g the authorizat­ion of another booster shot this spring.

The timing of that decision — and who would be eligible — remains unclear. But for older residents or those with underlying health conditions that make them more likely to develop a severe COVID-19 illness, another booster could provide peace of mind and an additional jolt of protection.

“Lots of people at higher risk are asking whether or not they need another dose. And we’re waiting for guidance on that,” Los Angeles County Public Health Director Barbara Ferrer said.

Authoritie­s in Britain have already green-lighted a spring booster shot — but only for nursing home residents, seniors 75 or older or those who are immunosupp­ressed and at least 5 years old.

“This year’s spring program will bridge the gap to the planned booster program in the autumn, enabling those who are most vulnerable to be well-protected throughout the summer,” Dr. Wei Shen Lim, chair of Britain’s Joint Committee on Vaccinatio­n and Immunizati­on, said in a statement.

Canada’s National Advisory Committee on Immunizati­on is suggesting a similar approach: making a spring booster available for those 65 or older as well as immunosupp­ressed adults and nursing home residents.

It remains to be seen how much of an appetite there could be for an additional booster in the U.S.

Even though uptake of the updated booster shot in Canada has also been relatively low, officials

there said it would be beneficial to offer additional doses.

“We have historical­ly seen patterns of waning protection against severe disease by six months after the last dose, particular­ly in older adults without prior infection,” Dr. Shelley Deeks, chair of Canada’s National Advisory Committee on Immunizati­on, said in a statement.

Emerging data demonstrat­e that those who get the bivalent booster shot are better protected against hospitaliz­ation and death, with the benefit particular­ly pronounced among older individual­s.

Among people age 65 to 79 in L.A. County, for instance, those who got the updated booster had one-tenth the risk of being hospitaliz­ed compared with those who are unvaccinat­ed, and roughly half the risk of being hospitaliz­ed compared with those who are vaccinated but haven’t received the bivalent booster.

Even among younger adults, in their 30s and 40s, the benefits were noticeable. Those who got the updated booster had one-sixth the chance of being hospitaliz­ed than unvaccinat­ed people, and roughly half the chance of being hospitaliz­ed compared with vaccinated people who hadn’t gotten the updated booster.

The same goes with deaths. Those age 65 to 79 who got the updated booster were about one-tenth as likely to die from COVID-19 compared with unvaccinat­ed people. They were roughly half as likely to die compared with vaccinated people who hadn’t received the updated booster.

Even with the terminatio­n of many COVID-19 emergency declaratio­ns, officials are stressing vigilance. And vaccinatin­g those most at risk remains a key focus moving forward — particular­ly as the disease continues to kill thousands of people a week worldwide.

“These (deaths) are largely among individual­s who are of older age, they may not have been vaccinated or received the full number of doses that are required for them at their age,” said Maria Van Kerkhove, the World Health Organizati­on’s technical lead on COVID-19. “So the threat remains.”

If authorized by U.S. health officials, additional doses of bivalent vaccine — designed to protect against Omicron subvariant­s that once dominated the coronaviru­s landscape — will, like in Britain and Canada, probably be made available for older people or others at higher risk of severe COVID-19 complicati­ons.

Dr. Peter Hotez, a pediatrics, molecular virology and microbiolo­gy professor at Baylor College of Medicine, has been a prominent supporter of making a second updated booster shot available, given what’s known about COVID vaccines’ waning protection over time.

“Uptake of the second (updated booster) may only be around 10 percent,” Hotez tweeted. “But for those who want it — especially the immunocomp­romised — they should have that option.”

Health officials have for months touted the benefits of the bivalent boosters, saying they provide added protection against infection, and especially against severe illness.

Some residents, especially those boosted recently, may have been unclear that the latest shot was formulated differentl­y, or felt they didn’t need it.

Hotez said he’s struck by how many people don’t know an updated booster came out in September.

“We still have a lot of vaccine education that needs to be done,” he wrote.

Others could simply be sick of rolling up their sleeves after already receiving multiple shots over the last two years.

The reduced severity of COVID-19 this last winter is likely due to a combinatio­n of factors, including the fact that older vaccine shots and earlier infections still provide a considerab­le degree of immunity; a plentiful supply of anti-COVID therapeuti­c drugs such as Paxlovid; and the relative stability of the dominant coronaviru­s strain — which has remained some subvariant of Omicron for more than a year.

For the public, there’s an expectatio­n that COVID-19 vaccines may mirror flu shots in the U.S.: one dose, formulated and administer­ed annually.

That approach could bear some fruit. A recent survey from the Kaiser Family Foundation found 53 percent of adults said they were somewhat or very likely get a COVID vaccine if it were offered annually.

That would be similar to the typical uptake of the flu vaccine. About 48 percent of U.S. adults have received the flu shot this season, according to the U.S. Centers for Disease Control and Prevention.

“We can, as we all know, get both vaccines on the same day, one in each arm,” Ferrer said. “And then we’ll have some protection­s going into what is usually the season with the highest number of respirator­y viruses.”

 ?? Tribune News Service file photo ?? Los Angeles Department of Public Health RN Jeremy Oyague administer­s a COVID-19 booster.
Tribune News Service file photo Los Angeles Department of Public Health RN Jeremy Oyague administer­s a COVID-19 booster.
 ?? Mel Melcon/TNS ?? Los Angeles nurse Angela Tapia prepares a dose of the Moderna booster. Health officials tout a new round of boosters.
Mel Melcon/TNS Los Angeles nurse Angela Tapia prepares a dose of the Moderna booster. Health officials tout a new round of boosters.

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