Important Facts About DOVATO

This is only a brief summary of important information about DOVATO and does not replace talking to your healthcare provider about your condition and treatment. What is the most important information I should know about DOVATO?

If you have both human immunodeficiency virus-1 (HIV-1) and hepatitis B virus (HBV) infection, DOVATO can cause serious side effects, including:

• Resistant HBV infection. Your healthcare provider will test you for HBV infection before you start treatment with DOVATO. If you have HIV-1 and hepatitis B, the hepatitis B virus can change (mutate) during your treatment with DOVATO and become harder to treat (resistant). It is not known if DOVATO is safe and effective in people who have HIV-1 and HBV infection.

• Worsening of HBV infection. If you have HIV-1 and HBV infection, your HBV may get worse (flare-up) if you stop taking DOVATO. A “flare-up” is when your HBV infection suddenly returns in a worse way than before. Worsening liver disease can be serious and may lead to death.

° Do not run out of DOVATO. Refill your prescription or talk to your healthcare provider before your DOVATO is all gone.

° Do not stop DOVATO without first talking to your healthcare provider. If you stop taking DOVATO, your healthcare provider will need to check your health often and do blood tests regularly for several months to check your liver.