Moderna vaccine mostly effective against variants

Moderna’s vaccine is effective against new variants of the coronavirus that have emerged in Britain and South Africa, the company announced Monday. But it appears to be less protective against the variant discovered in South Africa, and so the company is developing a new form of the vaccine that could be used as a booster shot against that virus. “We’re doing it today to be ahead of the curve should we need to,” said Dr. Tal Zaks, Moderna’s chief medical officer. “I think of it as an insurance policy.” He added, “I don’t know if we need it, and I hope we don’t.”

Moderna reported findings from a study that used blood samples from eight people who had received two doses of the vaccine and two monkeys that had also been immunized.

The British variant had no effect on the levels of neutralizing antibodies — the type that can disable the virus — produced after vaccination. But with the South African form, there was a sixfold reduction in those levels.

Even so, the company said, those antibodies “remain above levels that are expected to be protective.” Moderna collaborated on the study with the Vaccine Research Center at the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health.

The results have not been published or peer-reviewed yet but have been submitted to bioRxiv, which posts preliminary studies online.

The British variant has been found in at least 20 states, but the Brazilian and South African versions have not been detected in the United States.

Zaks said that the new version of the Moderna vaccine, aimed at the South African variant, could be used if needed as a booster one year after people received the original vaccine.