Atlantic Coast Louisville 48, Florida State 16:

No. 1 Clemson 47, Syracuse 21:

At Clemson, S.C., Travis Etienne ran for three TDs for the Tigers (6-0, 5-0), who beat the 45-pointunderdog Orange (1-5, 1-4) to open 6-0 for the sixth straight season with their 27th straight league win.

No. 3 Notre Dame 45, Pittsburgh 3: At Pittsburgh, Ian Book passed for 312 yards and three TDs, two of them long catch-and-runs by Ben Skowronek, for the Fighting Irish (5-0, 4-0), who dealt the Panthers (3-4, 2-4) their fourth straight loss.

No. 11 Miami 19, Virginia 14: At Miami Gardens, Fla., Mike Harley had 10 catches for 170 yards and a TD for the Hurricanes (5-1, 4-1), who dealt the Cavaliers (1-4, 1-4) their fourth straight loss. Brennan Armstrong threw for two TDs for Virginia.

No. 14 North Carolina 48, No. 23 North Carolina State 21: At Chapel Hill, N.C., Javonte Williams ran for 160 yards and three TDs to lift the Tar Heels (4-1, 4-1) past the Wolfpack (4-2, 4-2) in the teams’ first meeting as ranked teams since 1993.

Wake Forest 23, No. 19 Virginia Tech 16: At Winston-Salem, N.C., walk-on freshman safety Nick Anderson had three interceptions, and Christian Beal-Smith ran for 129 yards to lift the Demon Deacons (3-2, 2-2) past the Hokies (3-2, 3-2).

At Louisville, Ky., Javian Hawkins ran for 174 yards and three TDs for the Cardinals (2-4, 1-4), who amassed 569 yards to rout the Seminoles (2-4, 1-4) and halt a four-game skid.

Boston College 48, Georgia Tech 27: At Boston, Phil Jurkovec threw for 145 yards and two TDs and ran for 94 yards for the Eagles (4-2, 3-2), who beat the Yellow Jackets (2-4, 2-3) for the first time since 2007.