Los Angeles Times

Criteria vary for diagnosing brain deaths

Many hospitals have not adopted standard protocols, resulting in a ‘ disconcert­ing’ potential for error.

- By Melissa Healy melissa. healy@ latimes. com Twitter: @ LATMelissa­Healy

When it comes to diagnosing brain death, policies that vary from hospital to hospital could open the door to unthinkabl­e errors. Yet protocols designed to ensure that brain death gets diagnosed the right way every time have been adopted unevenly across the United States, new research shows.

In some cases, hospitals do not require doctors to follow protocols that would rule out conditions that mimic brain death but that can be improved with proper treatment. In other cases, hospitals have adopted cumbersome procedures that delay the proper diagnosis of brain death, putting patients in need of donor organs at risk, according to a report published in the journal JAMA Neurology.

Neurologis­ts recognize that the doctors who are asked to make the crucial call for profoundly unresponsi­ve patients are not always steeped in the diagnostic fine points of brain death, and they may lack the means to identify it with complete confidence. So in 2010, the American Academy of Neurology wrote a clear set of standards and procedures to distinguis­h a brain- dead patient from one who might emerge from an apparent coma.

The report, published Dec. 28, makes clear that many hospitals surveyed between 2012 and 2015 had not adopted these guidelines.

“This is disconcert­ing,” said David Magnus, a Stanford University medical ethicist who helped draft Stanford Health Care’s brain death protocols. The match between hospital rules and the American Academy of Neurology’s guidelines “should be 100%,” he said.

In some states, any physician can make the diagnosis of brain death. Other states have laws that dictate the precise level of medical expertise a doctor must have to make such a decision.

In addition, some states demand a confirmato­ry di- agnosis by a second physician or require a given period of time to elapse before brain death may be declared. Others do not.

Experts outlined several scenarios that show how this variabilit­y can lead to serious problems.

For instance, hypothermi­c patients who have been f ished out of freezing water or snow may satisfy many of the criteria for brain death, but will often recover when warmed. Despite this, only 36% of hospitals surveyed said they required physicians to determine whether a patient’s core body temperatur­e has reached nearnormal levels before making a declaratio­n of brain death.

Similarly, ingestion of certain drugs sometimes mimics the loss of primitive ref lexes seen in those with no remaining brain activity. But only about 32% of hospitals surveyed required testing to rule out the possibilit­y of toxic drug levels.

Other hospital protocols called for tests that have not been found useful in making a diagnosis of brain death. While conferring no greater certainty of brain death, these time- consuming extra steps can lessen the likelihood that a brain- dead patient’s organs would be donated to someone in need of a transplant.

Martin Monti, a UCLA expert on coma and other disorders of consciousn­ess, emphasized that when it comes to diagnosing brain death, “the science is there.” Given that unusual consensus, neurologis­ts are right to “be pushy” and encourage hospitals to translate that science into practice every time, he said.

Diagnosing someone as brain dead when he or she is not would be a horrific error, Monti said. But measures that delay a correct diagnosis and reduce the availabili­ty of transplant­able organs are also unacceptab­le because they may deny a potential beneficiar­y a chance at life.

“This paper is a beautiful example of how good science and medicine and good practice go hand in hand,” Monti said. “The problem is that we really need to have an extremely uniform way of doing this because the devil really is in the details.”

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