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In June, enrollment starts for the largest-ever lifestyle study on preventing cognitive decline. The Alzheimer’s Association–funded U.S. POINTER study is looking for 2,500 symptom-free participants who are at risk for Alzheimer’s, ages 60 to 79. In a brand-new twist in clinical trials, local Alzheimer’s Association offices, the YMCA and other community groups will work with researchers to evaluate the impact of two lifestyle interventions on brain health in participants across five U.S. regions. (First up: Wake Forest, N.C., and Northern California.) Visit alz.org/us-pointer to ask about enrolling.