Los Angeles Times

Is Diabetic Macular Edema getting in the way of your eyes?

- EYLEA is a registered trademark of Regeneron Pharmaceut­icals, Inc. © 2018, Regeneron Pharmaceut­icals, Inc. All rights reserved. 777 Old Saw Mill River Road, Tarrytown, NY 10591

See how EYLEA may be able to help.

On average, people with DME gained 10 more letters on the eye chart after 1 year on EYLEA in 2 clinical studies.

Visit DiscoverEY­LEA.com or Call 833-EYLEA-TV INDICATION­S

EYLEA® (aflibercep­t) Injection is a prescripti­on medicine approved for the treatment of patients with Wet Agerelated Macular Degenerati­on (AMD), Macular Edema following Retinal Vein Occlusion (RVO), Diabetic Macular Edema (DME), and Diabetic Retinopath­y (DR) in patients with DME.

IMPORTANT SAFETY INFORMATIO­N

• EYLEA® (aflibercep­t) Injection is a prescripti­on medication administer­ed by injection into the eye. You should not use EYLEA if you have an infection in or around the eye, eye pain or redness, or known allergies to any of the ingredient­s in EYLEA, including aflibercep­t. • Injection into the eye with EYLEA can result in an infection in the eye and retinal detachment (separation of retina from back of the eye). Inflammati­on in the eye has been reported with the use of EYLEA. • In some patients, injections with EYLEA may cause a temporary increase in eye pressure within 1 hour of the injection. Sustained increases in eye pressure have been reported with repeated injections, and your doctor may monitor this after each injection. • There is a potential risk of serious and sometimes fatal side effects related to blood clots, leading to heart attack or stroke in patients receiving EYLEA.

• Serious side effects related to the injection procedure with EYLEA are rare but can occur including infection inside the eye and retinal detachment. • The most common side effects reported in patients receiving EYLEA are increased redness in the eye, eye pain, cataract, moving spots in the field of vision, increased pressure in the eye, and vitreous (gel-like substance) detachment. • It is important that you contact your doctor right away if you think you might be experienci­ng any side effects, including eye pain or redness, light sensitivit­y, or blurring of vision, after an injection. • EYLEA is for prescripti­on use only. For additional safety informatio­n, please talk to your doctor and see the full Prescribin­g Informatio­n for EYLEA. You are encouraged to report negative side effects of prescripti­on drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. Please see the Consumer Brief Summary on the adjacent pages.

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