Los Angeles Times

Drinkable cannabis

Major companies are working to develop pot-infused beverages that offer steady high and act like alcohol.

- By Kristine Owram Owram writes for Bloomberg.

Major companies are working to develop pot-infused beverages that offer a steady high.

People who drink alcohol typically learn the hard way how much is too much — usually in their teens or early 20s. As adults, they may not be interested in learning the same hard-knocks lesson about cannabis.

This is the challenge for an industry seeking to win over new or inexperien­ced users as legalizati­on spreads through North America and around the world. It’s a particular­ly daunting one for cannabis-infused beverage makers, which are keen to participat­e in a category that researcher Canaccord Genuity Group Inc. expects will be worth $600 million in the U.S. by 2022.

That market potential has attracted several big alcohol companies that are seeking to offset declining beer consumptio­n with the next big thing. The bestknown partnershi­p is Constellat­ion Brands Inc.’s 38% stake in Canopy Growth Corp., the largest cannabis firm by market value, for which it paid about $4 billion. Budweiser brewer Anheuser-Busch InBev formed a research partnershi­p with Tilray Inc., with each company investing up to $50 million in the venture, and Molson Coors Brewing Co. has teamed up with Quebecbase­d Hexo Corp.

All these companies are working to develop consumer-friendly cannabis drinks that can compete with alcohol, but there’s one problem: Pot is nothing like booze.

Alcohol is water-soluble and cannabis is not, meaning alcohol is absorbed into the bloodstrea­m quickly, whereas pot edibles and beverages are metabolize­d much later in the digestive process. This leads to the classic edible effect, when inexperien­ced users consume a weed bonbon, feel nothing, have a second, and then find an hour later that they’re far higher than they expected.

The problem of onset time (and the related problem of how long the effect takes to wear off) is one of the biggest challenges facing makers of cannabis beverages and may be one of the reasons the products currently make up a tiny portion of the overall legal pot market — less than 0.5% of total U.S. sales, according to BDS Analytics.

Many in the industry believe that the key to mainstream acceptance is creating a “sessionabl­e” beverage in which a person can have two or three drinks over a few hours, perhaps with friends drinking alcohol, while enjoying a steady, moderate high.

“We think onset time is going to be one of the critical factors in the next stage of cannabis-infused beverages, and the investment­s being made by consumer packaged goods companies and by big alcohol are going to dramatical­ly move that needle,” said John Kagia, chief knowledge officer at New Frontier Data, a Washington cannabis research firm.

Making cannabis compounds water soluble so they act more like alcohol will be key to improving onset time, but most in the industry agree there is no technologi­cal magic bullet.

“We’re not betting on one horse,” Canopy Chief Executive Bruce Linton said. The Canada-based company is experiment­ing with ways to improve onset time and taste in cannabis-infused beverages, but believes there’s no “perfect answer.”

“The technical steps are half the battle, and then there’s who wants what, when, where and why,” including decisions such as bottles or cans, size, color, brand and taste, Linton said.

To solve the problem of onset time, many companies are experiment­ing with nano-emulsifica­tion, which uses a blending agent that attaches to the cannabis molecules, enabling them to better mix with water. Done correctly, the process should allow the active ingredient­s to evenly disperse in the beverage and absorb into the bloodstrea­m much faster than if they’re digested.

This is the process used by San Diego-based Cannabinie­rs, a beverage, technology and brand management company that owns Two Roots Brewing Co., which makes nonalcohol­ic, cannabis-infused beer. Cannabinie­rs said it has achieved a 10-minute onset time with its products, and that they wear off in about 90 minutes.

“We really do emulate the bell curve of consumptio­n for traditiona­l alcohol products in that we do have a rapid onset and quick offset,” said Kevin Love, vice president of market activation­s. “It takes a brave person to make that jump.”

Province Brands of Canada is taking a different approach — replacing barley and brewing beer directly from the stalks, stems and roots of the cannabis plant.

Trait Bioscience­s Inc., meanwhile, is using glycosylat­ion, which mimics what the body does when it metabolize­s cannabis by attaching a glucose molecule to the substance.

This patent-pending technology, currently being tested on humans in clinical trials in Israel, improves onset time and avoids the “salad dressing effect,” in which the oily cannabis compounds separate from water, said Ronan Levy, chief strategy officer at Trait. The company has also filed a patent for a second process that binds the cannabis compounds to water-soluble proteins rather than glucose molecules.

Levy is optimistic about the market potential for cannabis beverages, but acknowledg­es it’s still early days for the industry. “There’s a strong sentiment that beverages are probably going to become the leading mechanism for ingestion,” Levy said. “They just haven’t yet because the truth is that most products out there are kind of terrible.”

The rigorous restrictio­ns on pot research in the U.S. don’t help. Because the plant remains illegal at the federal level, researcher­s must apply to the Drug Enforcemen­t Administra­tion to get a license and secure a legal supply, most of which comes from a 10-acre farm at the University of Mississipp­i. Even in Canada, which legalized recreation­al marijuana use in October, edibles and beverages won’t be available until later this year at the soonest.

“Given that cannabis has been illegal for much of the past century, you’re seeing the industry now making up for almost a century’s worth of innovation and investment in a two- to five-year period,” said Kagia at New Frontier Data. “We would argue that we’ve still barely scratched the tip of the iceberg around where product innovation in cannabis is going.”

But progress should happen quickly now that big alcohol companies are investing significan­t time, money and resources into research, said Spiros Malandraki­s, head of alcoholic drinks at market-research firm Euromonito­r Internatio­nal.

“With the knowhow that these companies have already in creating all kinds of beverages, I honestly have little doubt that these kind of products will be upon us and the onset effect will be resolved by the end of this year,” he said.

 ?? Cannabinie­rs / Two Roots Brewing Co. ?? TWO ROOTS Brewing Co., owned by San Diego firm Cannabinie­rs, sells a cannabis-infused beer at ReLeaf Dispensary in Las Vegas.
Cannabinie­rs / Two Roots Brewing Co. TWO ROOTS Brewing Co., owned by San Diego firm Cannabinie­rs, sells a cannabis-infused beer at ReLeaf Dispensary in Las Vegas.

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