Los Angeles Times

AstraZenec­a got taxpayer funding—but aggressive­ly raised prices.

The steep hikes came even as AstraZenec­a received $1.2 billion from taxpayers for vaccine developmen­t.

- By Noam N. Levey

WASHINGTON — One of the world’s largest drug companies has been aggressive­ly raising prices even as it received hundreds of millions of dollars of U.S. government aid to develop a COVID-19 vaccine.

AstraZenec­a, which the Trump administra­tion has lauded for its vaccine work, boosted prices despite renewed promises by President Trump this summer to keep drug costs in check.

The multinatio­nal pharmaceut­ical firm raised prices in a way that stood out even among other big drug companies. It announced not just one set of price hikes in 2020 but two, often on the same drugs, according to an analysis of drug pricing data by The Times and 46brooklyn Research, a nonprofit that studies the pharmaceut­ical industry.

AstraZenec­a hiked prices on some of its biggestsel­ling medicines by as much as 6% this year at a time when the overall inflation rate is hovering around 1%, the analysis shows. The administra­tion has said nothing about the price increases.

AstraZenec­a’s second round of increases came after it secured a $1.2-billion commitment in May from the U.S. for vaccine developmen­t and as the company was reporting more than $3.6 billion in operating profit in the first half of 2020.

“They clearly made a decision to do their pricing differentl­y, both from their recent past and from their peers, at the same time they were seeking billions of dollars,” 46brooklyn founder Eric Pachman said.

AstraZenec­a, which is based in Britain but also has a large U.S. operation, declined to discuss its pricing practices, instead offering a statement noting the company’s assistance programs for people unable to afford its drugs. “We recognize the challenges many Americans are facing and remain committed to ensuring patients are able to access our medicines,” the statement said.

The company’s price hikes underscore­d the persistent inability of U.S. policymake­rs, including Trump, to rein in drug prices, even during a public health crisis when pharmaceut­ical companies are getting substantia­l public assistance.

“Pharma corporatio­ns are sophistica­ted political actors that understand this is a risky time to be seen increasing prices, and yet these corporatio­ns are addicted to price increases,” said Peter Maybarduk, who oversees drug policy for the nonprofit watchdog group Public Citizen.

Although the federal government has committed more than $10 billion this year to drug companies to develop a COVID-19 vaccine, the administra­tion hasn’t required any commitment­s from drugmakers on the price they would charge.

Thus far, companies receiving government aid have only made vague promises to make any vaccines they develop affordable.

AstraZenec­a has said it wouldn’t profit from vaccine sales during the pandemic, but it remains unclear how this would be verified and whether the company might raise prices after the worst of the crisis passes.

Drugmakers for years have pledged to make their products more affordable, assuring U.S. lawmakers, patient groups and others that they are sensitive to the struggles many Americans have paying for their medication­s.

Yet patients in the U.S. are finding it increasing­ly difficult to afford prescripti­ons, with 1 in 5 households reporting last year that they were unable to pay for a medicine that a doctor had prescribed in the previous year because of costs.

Neverthele­ss, to start this year, most major pharmaceut­ical companies continued to hike prices at rates far exceeding inflation, The Times and 46brooklyn found.

Several of the world’s biggest drugmakers announced hikes of 5%, 6%, even 9% on a host of popular medicines, according to the analysis, which looked at list prices by the 15 largest drug companies using the Elsevier Gold Standard Drug Database, which includes pricing and clinical informatio­n on tens of thousands of medication­s.

List prices are typically higher than the final prices health insurers and government­s negotiate with drugmakers. But the list price guides negotiatio­ns and can have a major effect on what patients pay, especially as high-deductible plans increasing­ly require people to pay the list price until the deductible is met.

Moreover, in Medicare’s Part D, the nation’s largest prescripti­on drug program, patients’ out-of-pocket costs for drugs typically rise when the list prices for drugs go up.

Other wealthy countries in Europe, East Asia and elsewhere more aggressive­ly control the cost of medication­s, either directly through government pricesetti­ng or indirectly through tightly regulated price negotiatio­ns. That has protected patients in these countries from the cost burdens that now routinely overwhelm Americans, studies show.

At the start of the year, AstraZenec­a’s 2020 price hikes initially looked relatively modest.

The company announced only 13 price increases in January, averaging 2.7% and not exceeding 3%, a threshold that is historical­ly in line with inf lation and typically attracts minimal attention.

Those hikes suggested that the company would be implementi­ng among the least aggressive pricing strategies in the industry.

Only Swiss drugmaker Roche raised its prices by a lower average, according to the Times-46brooklyn analysis.

By contrast, AbbVie, an American manufactur­er, increased prices on many of its drugs by more than 7%, including a 7.4% hike for its popular Humira medication. That followed a 6.2% increase on Humira in 2019.

Shortly after AstraZenec­a’s January price increases, as the COVID-19 pandemic quickly spread across the globe, the company began talks with Oxford University to produce a vaccine initially developed by researcher­s at the British school. A formal agreement was signed at the end of April.

By mid-May, the drug giant had secured $1.2 billion from the U.S. Department of Health and Human Services. The department heralded the grant as paving the way for a major clinical trial in the U.S. and the production of what the Trump administra­tion said would be more than 300 million doses of a vaccine.

Health and Human Services Secretary Alex Azar, a former executive at U.S. drugmaker Eli Lilly, called the award “a major milestone.” AstraZenec­a last week put its clinical trials on hold after a participan­t developed a potentiall­y serious complicati­on.

The company received money from other government­s over the summer as well. European nations — through the European Inclusive Vaccines Alliance and the European Union — put forward more than $1 billion. AstraZenec­a signed deals with Japan, China, Brazil and other nations too.

At the same time, the company reported that its revenue for the first half of the year had increased 14%. Operating profit surged more than 20% from the first six months of 2019, according to the company’s earnings report.

Pascal Soriot, the company’s chief executive, at the time hailed the “strong performanc­e” as “another step forward in profitabil­ity and cash generation.”

Neverthele­ss, AstraZenec­a raised its prices again, announcing hikes in July on 10 more drugs. Unlike in January, the increases weren’t so modest.

The company pushed up the price on two drugs by 5%, including its popular Pulmicort, a steroid used to treat Crohn’s disease that the company reported generated nearly $1.5 billion in sales in 2019.

AstraZenec­a also boosted prices by 6% on Nexium and Crestor, two old blockbuste­rs that now have generic competitor­s but together still generate more than $300 million in U.S. sales, and much more globally. The two drugs are nearly 20 years old.

The company also raised prices on some of its most expensive drugs after holding off increases in January. Those included Tagrisso, one of the company’s bigselling cancer drugs, which costs more than $15,000 for a monthly supply. AstraZenec­a increased Tagrisso’s price tag by 2% in July.

In addition to these increases, AstraZenec­a raised prices a second time on 11 of the 13 drugs it had already bumped up in January.

That pushed the total 2020 price increases for most of these drugs to 5% or 6% as well.

No other major drug company made as many double price increases in 2020, the Times-46brooklyn analysis shows.

GlaxoSmith­Kline, another British pharmaceut­ical firm, raised prices twice on four drugs, the second most among the 15 major drug companies. Eight such companies didn’t implement a single double increase in 2020.

“AstraZenec­a is the real outlier in 2020,” Pachman said.

In one nationwide survey earlier this year, 9 in 10 Americans said they were concerned that the pharmaceut­ical industry would take advantage of the current pandemic to increase prices.

Sensitive to voters’ concerns, Trump this summer said he would undertake new efforts to control prices, a promise he had made a centerpiec­e of his 2016 presidenti­al campaign.

To date, none of the administra­tion’s major proposals to restrict prices have been fully implemente­d.

 ?? Alastair Grant Associated Press ?? BRITISH company AstraZenec­a increased prices on some of its biggest-selling medicines by as much as 6% this year at a time when the overall inflation rate is hovering around 1%. Above, its offices in Cambridge.
Alastair Grant Associated Press BRITISH company AstraZenec­a increased prices on some of its biggest-selling medicines by as much as 6% this year at a time when the overall inflation rate is hovering around 1%. Above, its offices in Cambridge.

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