Los Angeles Times

Antibody treatment is harder to get

Health officials in California are warning of shortages and distributi­on problems.

- By Rong-Gong Lin II and Luke Money

Health officials in California are warning of shortages and distributi­on problems for a medical treatment that can keep COVID-19 patients from falling critically ill.

Monoclonal antibodies have been developed as a treatment for COVID-19. They are thought to be a way to counteract the coronaviru­s before it can begin destroying the body’s organs, said Dr. Rais Vohra, interim health officer for Fresno County. The antibodies can be used to treat mild or moderate COVID-19 in patients who are not hospitaliz­ed.

The nation has recently seen an exponentia­l increase in demand for monoclonal antibodies; as a result, the U.S. Department of Health and Human Services is reserving the treatment for areas hit hardest by the pandemic, according to Dr. Regina Chinsio-Kwong, a deputy health officer for Orange County.

“Because of this, we likely are going to see a drop in monoclonal antibody access for our county,” ChinsioKwo­ng said. Healthcare providers are being asked to prioritize the highest-risk people for the therapy.

In Central California, widespread distributi­on of monoclonal antibody treatments has been challengin­g, Vohra said. In addition to being difficult to order from the state and from manufactur­ers, the therapy requires nursing staff to administer it, in a process that can take up to three hours. It’s also a challenge in crowded hospitals to find space for patients to get the infusions.

“A lot of our clinics and hospitals are just saying that they don’t have the resources to commit that amount of time,” Vohra said.

While not a substitute for vaccinatio­ns, monoclonal antibodies are a promising therapeuti­c, Vohra said, noting that it’s unfortunat­e when a medication can’t be administer­ed because of staffing and infrastruc­ture problems.

“Every patient that gets an infusion today, we may actually save them an [intensive care unit] hospitaliz­ation in just a couple of weeks from now, so it’s definitely worth investing in this,” he said.

Vohra said he’d like to see the state increase access to monoclonal antibody treatments for more California­ns.

“Let’s be realistic: COVID is not going to go away anytime soon,” he said. “We hope we can get it under control, but there’s always going to be patients that come in ... and if they’re at high risk, this is going to be one of the first medication­s that we reach for, regardless of whether we’re in a surge or not.

“So we really do need to build the infrastruc­ture around giving monoclonal antibodies. Because if we don’t nip their problem in the bud, then it is going to bloom into a bilateral pneumonia or something else that will land them into the ICU,” Vohra said.

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