Jaguars ................... 24 Colts ............................ 0

Trevor Lawrence threw two touchdown passes to Christian Kirk, and Jacksonville dominated short-handed Indianapolis for its eighth straight home win in the series.

The Jaguars sacked Matt Ryan five times, intercepted three of his passes, held reigning NFL rushing champion Jonathan Taylor to 54 yards and notched their eighth shutout in franchise history as Doug Pederson recorded his first win with Jacksonville.

Lawrence completed 25 of 30 passes for 235 yards against a Colts defense missing All-Pro linebacker Shaquille Leonard. Indianapolis also was without receivers Michael Pittman and rookie Alec Pierce.