Hang on with Familia

second on a wild pitch and then scored on Marlon Byrd’s single to right-center field. After putting the go-ahead run on base by walking Juan Uribe, Familia coaxed a fly-out from Jose Ramirez.

There were some panicked whispers about Collins using Familia Wednesday for a five-out save after Jim Henderson struggled in backto-back appearances. The closer, who threw 78 innings last season, shook them off.

“I am fine. Everybody is tired down there (in the bullpen), but tie games or when we are winning, we got to pitch,” Familia said of having had such a heavy workload already. “I feel OK. It’s my job. The day off (Thursday) helped.”

So did the fact that the Mets took a 6-1 lead.

Conforto homered off Indians right-hander Cody Anderson on the second pitch he saw.

De Aza led off the fifth inning inning with a home run to dead-center field. Conforto worked a two-out single before Cespedes, who was the DH because he was still feeling the sting in his legs from jumping into the stands trying to snare a foul ball Wednesday, crushed a line-drive, two-run homer to chase Anderson after just 4.2 innings. With Lucas Duda on first, the Indians brought in Ross Detwiler to face Neil Walker, who hammered the Mets’ third homer of the inning. It was the first time the Mets hit three home runs in an inning on the road since 2006, when Cliff Floyd, Carlos Beltran and David Wright did it at Wrigley Field.

That was it for the Mets’ offense. They went 0-for-10 with runners in scoring position. Collins was not concerned about the Mets’ inability to play small ball and move runners from station to station.

“We won the game,” Collins said when asked about the missed opportunities.

Having scored a major-league low 20 runs over the first eight games, Collins changed the lineup, putting Conforto in the three spot ahead of Cespedes.

“We’ll try it another day, I know that,” Collins said.