Orlando Sentinel (Sunday)

Experts: DeSantis leaving out key facts

- By Steven Lemongello and Caroline Catherman

Speaking in Panama City on Jan. 13, Gov. Ron DeSantis told reporters, “clearly the vax has not stopped people from being infected with omicron. That is just clear as day.”

“They had said it would end COVID,” DeSantis declared.

Like many of DeSantis’ comments about the coronaviru­s, it did not tell the whole story.

DeSantis’ statements about vaccine effectiven­ess and safety, antibody treatments and the power of natural immunity are cloudy in some cases and absolutely wrong in others, say epidemiolo­gists and other experts interviewe­d by the Orlando Sentinel.

Mac Stipanovic­h, a Tallahasse­e consultant and former anti-Trump Republican turned independen­t, said DeSantis’ motivation is political. The governor is

courting anti-vax Republican­s in advance of the 2024 GOP primary for president, he said.

“They stress two things out of the three things they could stress,” Stipanovic­h said of the DeSantis administra­tion. “They stress therapeuti­cs, which is treatment after infection, then they stress natural immunity after infection, and the only thing they don’t stress is vaccinatio­n before infection. And it’s all part of a message that is heard, if not explicit.”

DeSantis spokeswoma­n Christina Pushaw disagrees, saying in an email that “everything the governor has said was factual.”

Here are five COVID-related issues addressed by the governor and what health officials have to say in response:

Vaccine effectiven­ess

DeSantis traveled the state in early 2021 promoting vaccinatio­ns. But since last May, DeSantis hasn’t held any events specifical­ly about vaccines or boosters.

In recent months, DeSantis has repeatedly downplayed the effectiven­ess of vaccines, instead choosing to promote monoclonal antibody treatments for the already infected.

“COVID vaccines are not preventing infection, okay, it’s just not,” DeSantis said on Nov. 18.

On Jan. 28, the governor said there was “a lot of distrust in some of these government officials because remember, they would say just six months ago, COVID shots mean you will not get COVID. That’s just not factually true.”

Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, said in April 2021 that COVID-19 vaccines were expected to become less effective over time at preventing infection, and boosters would likely be needed, particular­ly if a new variant emerged.

“We may have cycles where we have to keep boosting people,” Fauci told MSNBC in March 2021.

Today, vaccines continue to reduce people’s odds of serious disease, which means they are doing their job, said Tom Unnasch, a University of South Florida distinguis­hed health professor. Boosters help maintain that protection, he said.

A recent CDC report showed that the third dose of either the Pfizer or Moderna shots reduces the chance of hospitaliz­ation by 90% compared with unvaccinat­ed people, and reduces the chance of a trip to the emergency room by 82%.

“Vaccines are doing exactly what we hoped they would ... They are protecting against severe disease,” Unnasch said.

In addition, vaccines still offer some protection against transmissi­on, contrary to DeSantis’ assertion that they haven’t curbed the spread of omicron. Vaccinated people appear to spread the virus for a shorter period than unvaccinat­ed people, according to a vaccine guide posted online by Mayo Clinic staff on Feb. 4.

In response, Pushaw said “federal officials did make false statements,” citing comments from CDC Director Rochelle Walensky from April 2021 in which Wallensky said vaccinated people “don’t carry the virus.” Walensky’s statement, made prior to the delta variant becoming dominant over the summer, was immediatel­y called into question by health experts at the time and was quickly walked back by the CDC.

Natural immunity

On Jan. 28, Gov. Ron DeSantis told reporters, “The CDC just admitted that natural immunity was more protective than mRNA shots [vaccines]. That was obvious six months ago. … They finally have admitted that.”

That was an apparent reference to a CDC study that found for a few months last year during the delta surge, people who were vaccinated without any prior infection were more likely to test positive for COVID-19 than people who had previously been infected with the virus.

The study’s authors pointed out this was before most people had received booster doses to counteract waning vaccine immunity. They also said that when they started their study, vaccinatio­n appeared to have provided better protection than natural immunity, further suggesting that waning immunity could be at play.

Their takeaway was that vaccinatio­n is still the best way to protect yourself against COVID-19.

The potential risks of vaccines are far lower than the risks of trying to catch COVID-19 to gain natural immunity, the researcher­s say. Recent CDC data shows that boosters provide strong protection against severe disease from omicron.

“Vaccinatio­n remains the safest and primary strategy to prevent SARS-CoV-2 infections, associated complicati­ons, and onward transmissi­on,” the authors write.

Elena Cyrus, an infectious disease epidemiolo­gist at the University of Central Florida’s College of Medicine, said preventati­ve health measures could be more effective than a focus on treatment at keeping the population safe.

“Given that the state is having a problem with staff shortages, students out of school and other … problems … related to COVID-19 health outcomes, a prudent focus might be to focus on maintainin­g a healthier population that is less sick overall,” wrote Cyrus in an email.

“And the most efficient and cost-effective way to do that continues to be through vaccinatio­n and other public health measures aimed at prevention of illness to begin with,” she said.

Asked to respond, Pushaw cited the same CDC study previously mentioned.

Monoclonal antibodies

Last month, DeSantis lashed out at the FDA for

pulling the emergency use authorizat­ion for two monoclonal antibody treatments by Regeneron and Eli Lilly, calling the decision “unbelievab­le.”

The treatments have been the centerpiec­e of DeSantis’ COVID policy for months, in lieu of promoting vaccines.

At a press conference Jan. 26 and during a Jan. 28 roundtable, DeSantis criticized the science behind the decision.

“The study that they did was not a clinical trial, was not even done on human beings,” DeSantis said. “It was a lab study in vitro. And they basically said that it was not effective, dealing with it in a lab environmen­t.”

He is correct that the study was not a clinical trial, and it was done in a lab, not on humans.

But Dr. Michael Diamond, a Washington University School of Medicine professor and one of the scientists who worked on the study, said the main takeaway is that monoclonal antibodies are less effective against omicron. He said there is enough evidence to conclude the Eli Lilly and Regeneron treatments are “likely to lose efficacy completely.”

Since his article came out, another animal study in mice found the same thing: Regeneron is not as effective against omicron as it was against delta.

Dr. Mary Jo Trepka, an epidemiolo­gist at Florida Internatio­nal University, pointed out that even the companies who made the monoclonal antibody treatments agreed that they should be taken out of circulatio­n, something the governor does not mention in his criticism.

“Monoclonal antibody treatments are not without risks,” she said. “Therefore, they should not be given unless there is a clear potential benefit.”

Fertility and vaccines

In a press conference on Jan. 20 to announce funding for nursing certificat­ion programs, DeSantis slammed federal mandates for health care workers to get vaccinated. But one comment stuck out.

“Think about how ridiculous it is what they’re doing by trying to force the nurses”

to get vaccinated, he said. “A lot of these nurses have had COVID. A lot of them are younger. Some of them are trying to have families.”

The last comment drew national attention.

The vaccines do not affect a woman’s ability to become pregnant or harm pregnant women, health experts say. The consensus about the vaccine’s safety is so strong that every major maternal care organizati­on in the United States issued a joint statement strongly recommendi­ng vaccinatio­n.

The group included the American College of Obstetrici­ans and Gynecologi­sts, the American Academy of Family Physicians, the American College of Nurse-Midwives, and the Society for Maternal-Fetal Medicine.

“COVID-19 vaccines have no impact on fertility,” the statement read. “Pregnant individual­s and those

planning to become pregnant should feel confident in choosing vaccinatio­n to protect themselves, their infants, their families, and their communitie­s.”

At the same time, ample evidence suggests that pregnant women are at higher risk of severe complicati­ons from COVID-19 than non-pregnant women. This means the risks of catching COVID-19 outweigh the risks of vaccinatio­n for pregnant women, the CDC’s website states.

One recent study of Scottish mothers published in Nature found that unvaccinat­ed pregnant people with COVID-19 are more likely to be hospitaliz­ed than vaccinated momsto-be, and their babies are more likely to die soon after birth. An April study from University of Oxford researcher­s found women with a COVID-19 diagnosis were 22 times more likely to die during pregnancy.

“It is important to always acknowledg­e that the risk of vaccine-related side effects, despite being exceedingl­y small, is not zero,” said Jason Salemi, an epidemiolo­gist at the University of South Florida’s College of Public Health. “However, the risks associated with getting COVID-19

while pregnant — including of maternal death, stillbirth, and preterm delivery — far, far outweigh any risks associated with COVID-19 vaccinatio­n.”

Pushaw said DeSantis “didn’t say anything about fertility” and vaccines, though she also said it was “worth noting some women are concerned” about potential changes to their menstrual cycles.

She said the remark was instead about job security being important to start a family.

Lockdowns

At a Federalist Society event Friday at Walt Disney World, DeSantis was asked by former White House Press Secretary Kayleigh McEnany about a recent lockdown study.

“But on the subject of lockdowns, big study out this week that the leftist press is ignoring,” McEnany said. “Johns Hopkins University did a meta-study of 34 studies and found the lockdowns have little to no public health effects. … It seems like you were kind of vindicated by Johns Hopkins.”

“Yeah,” DeSantis responded. “... Lockdowns absolutely had a negative public health effect on people and certainly people who were by and large not terribly at risk from COVID.”

“When I look back at lockdowns, it was supposed to be ‘15 days to slow the spread,’ ” DeSantis continued. “Now these epidemiolo­gical models were totally, totally wrong. And those people should be held accountabl­e for that.”

As Canada’s National Post reported, what McEnany and DeSantis were discussing was not a study coming from Johns Hopkins’ Coronaviru­s Research Center, from which most of its COVID research has originated, but instead a “working paper” from three economists with the university’s Krieger School of Arts and Sciences.

The study, which was not published in a scientific journal and was not peer-reviewed, “only sought data on COVID mortality, and ignored the effects ... on other factors such as hospitaliz­ations or overall case rates,” the Post wrote.

It also excluded peer-reviewed studies such as the one published in Nature that calculated lockdowns saved 3 million lives in Europe in 2020.

The author of the Nature study, Seth Flaxman of the University of Oxford, criticized the paper’s methodolog­y along with several other researcher­s.

“They systematic­ally excluded from considerat­ion any study based on the science of disease transmissi­on, meaning that the only studies looked at in the analysis are studies using the methods of economics,” Flaxman wrote.

And while DeSantis decried “perpetual lockdown policies” as recently as Feb. 8, the vast majority of states ended their spring 2020 lockdowns within a few weeks of DeSantis’ own 30-day lockdown from April to May.

Only six states extended their 2020 lockdowns into June, and only California (August) and New Mexico (November) extended them any further. Since then, there have been no 2020-style lockdowns or stay-at-home orders, only stricter masking

and vaccinatio­n policies than in Florida.

DeSantis and his staff continuing to compare “lockdown states” with a “free” Florida, is “a sleight of hand,” Stipanovic­h said. “It equates masks with lockdowns, which isn’t the case. And they do that sort of thing all the time.”

Pushaw said, “Any policy that requires a person to show proof of COVID-19 vaccinatio­n or cover their faces in order to participat­e in everyday life is a ‘lockdown.’ ”

“You can define the word lockdown however you want, but the governor was referring to government-imposed restrictio­ns on movement,” Pushaw said.

‘A credibilit­y gap’

Kenneth Goodman, a bioethicis­t and director of the Institute for Bioethics and Health Policy at the University of Miami, criticized the “kooky views acquiring broad currency” among state leadership. But he agreed with Stipanovic­h that the ultimate motive is political.

“There are times when it serves a political interest to engender doubt,” he said. “And there’s a subset of politician­s who have tried really hard to spread doubt about scientific knowledge in the context of COVID.”

Goodman said the changing circumstan­ces of the virus and its mutations, and the continuing search for informatio­n about the virus and its mitigation, have been “weaponized in the interests of underminin­g.”

“When the experts have been mistaken, they’re criticized for not having been infallible, even though it’s a probabilis­tic science with a brand new virus and there’s really exciting, important science moving forward quickly,” he said. “... It’s been weaponized in the interest of advancing what I think most ordinary Americans regard as a sad and silly political agenda.”

“We used to call it a credibilit­y gap,” Goodman said of politician­s’ untrustwor­thiness. “Now, the problem is there are actually dead people as a result of it.”

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 ?? STEPHEN M. DOWELL/AP ?? Gov. Ron DeSantis and former White House press secretary Kayleigh McEnany speak during a “fireside chat” at the Florida chapter of the Federalist Society’s annual meeting at Disney’s Yacht Club resort in Walt Disney World on Feb. 4 in Lake Buena Vista.
STEPHEN M. DOWELL/AP Gov. Ron DeSantis and former White House press secretary Kayleigh McEnany speak during a “fireside chat” at the Florida chapter of the Federalist Society’s annual meeting at Disney’s Yacht Club resort in Walt Disney World on Feb. 4 in Lake Buena Vista.

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