Pittsburgh will power an international initiative to improve human health
The Magee-Womens Research Summit will bring together experts from around the world to remake the future, explains MICHAEL J. ANNICHINE of Magee-Womens Research Institute
Pittsburgh prides itself on medical innovation. From polio to organ transplants, CTE to Alzheimer’s, this region has proven itself a ripe ecosystem for important discoveries that are changing lives and reshaping human history.
In October, we have the opportunity to once again create this kind of impact, when experts in women’s health from around the world gather to showcase the most significant developments in the field.
The Magee-Womens Research Summit, which will run Oct. 9 and 10 at the David L. Lawrence Convention Center, aims to propel women’s health — traditionally one of the most understudied areas in medicine — to the forefront of an international conversation. Through the generosity of the R.K. Mellon Foundation, the summit will award the inaugural Magee Prize — at $1 million, it will be one of the largest medical prizes in any discipline. We are doing this for one reason: We think that a collaborative initiative in women’s health could dramatically improve human health across the lifespan, around the globe.
Our keynote speaker, Lara Logan, speaks poignantly of her firsthand experiences in navigating the health care system. While in Egypt’s Tahrir Square working for CBS News in 2011, she was brutally beaten and gang-raped by a mob of 200 to 300 men, leading to internal injuries and interstitial cystitis, from which she continues to recuperate. She has spent years pursuing an accurate diagnosis while working through excruciating pain.
Unfortunately, Ms. Logan is far from alone: A 2008 National Institute of Health study found that women wait longer than men to receive pain medication in emergency rooms. The National Institute for Health and Care Excellence found that one in 10 women suffer from endometriosis, but despite the disease’s prevalence, doctors take, on average, seven to eight years to diagnose it, in part because women’s reports of pain are not taken seriously enough. A year after the Tahrir Square attack, Ms. Logan was diagnosed with breast cancer. Even today, she hesitates to call herself a survivor, and she worries about recurrence. But she expresses hope in new therapies arising from the decoding of the human genome — therapies that are being developed at the Magee-Womens Research Institute, the largest research institute in the United States devoted exclusively to women’s health and reproductive biology. As recently as the 1970s, women were largely excluded from clinical trials and subjected to treatments that had been developed largely through the study of men, sometimes with tragic consequences. It was not until 1993 that Congress mandated adequate inclusion of women in NIH-sponsored clinical trials to help determine sex-based differences in disease manifestation and treatment. Today, we are working hard to overcome the barriers of the past. The Magee Obstetric Maternal & Infant Database and Biobank offers a wealth of biological samples linked to a webbased inventory system that is available to researchers both within and outside of our academic home. Tools such as these can accomplish so many critical goals. They can
produce safer products for pregnant women, reduce infant mortality and identify high-risk populations for specific disease states. They enable us to look retroactively at a disease that presents in a 10-year-old child to determine whether markers existed at birth that could have led to interventions that would have mitigated or eliminated the illness.
The research teams that will present at the summit will illustrate how a focused approach to women’s health can create a tremendous positive impact on all human life. By acknowledging that men and women are biologically different, and so must be treated differently medically, we can bring this era of precision medicine to bear on a wide swath of disease states. Just as we target cancer with precision — and are achieving success — an individualized approach to women’s health that recognizes sex differences also can move the needle.
The downstream effects of pre-term births, pregnancy complications such as preeclampsia and the hormonal, nutritional and environmental signals that influence fetal development are all areas ripe for further scientific exploration. Rather than look at these areas as the sole domain of reproduction, we must start recognizing them for what they are: the earliest predictors of the next nine decades of all human health.
The best way to serve the coming generations is to recognize the power of working together toward a healthier future. In the words of Henry Ford, “Coming together is a beginning; keeping together is progress; working together is success.”