Pittsburgh Post-Gazette

Most of Moderna’s doses going to wealthy countries

- By Emily Rauhala

In January 2020, a nonprofit with a mission to develop and equitably distribute vaccines invested $900,000 in a promising but untested bit of technology: Moderna’s coronaviru­s vaccine.

Announcing the grant, the Coalition for Epidemic Preparedne­ss Innovation­s touted an alignment of values, namely a shared commitment to global public health. Documents suggest U.S.-based Moderna agreed to uphold the group’s “equitable access principles” — the idea that vaccines should be distribute­d according to need and at affordable prices.

But more than year later, with the pandemic still raging, Moderna’s successful vaccine is anything but accessible. The company has sold most of the early doses to rich countries. Poorer countries have been almost entirely shut out.

Moderna “seems to have refused to allocate or sell any of their supply beyond the wealthiest countries, the most profitable markets,” said Suerie Moon, co-director of the Global Health Center at the Graduate Institute of Internatio­nal and Developmen­t Studies in Geneva.

Asked about the $900,000 grant, equitable access provisions and calls to make the Moderna vaccine widely available, company spokeswoma­n Colleen Hussey referred The Washington Post to a more than 3-month-old news release about thirdquart­er financial results, which noted that discussion­s with Covax — an initiative to equitably distribute vaccines around the world — were “ongoing.”

Moderna is certainly not the only coronaviru­s vaccine maker to enter into deals with rich countries. Just 16% of the world’s population has snapped up 60% of doses, according to an estimate from researcher­s at Duke University.

Moderna’s record stands out because none of its doses are yet earmarked for what the World Bank classifies as low-income nations.

Most of its competitor­s — Pfizer, AstraZenec­a, Sanofi and Johnson & Johnson — have already made commitment­s to Covax, an effort coled by its early backer, CEPI, as well as the World Health Organizati­on and Gavi, the Vaccine Alliance.

CEPI said it is still in talks with Moderna about supplying Covax but did not provide details on where things stand. The WHO, which coleads Covax and advocates for vaccine access, referred The Post to Gavi, which referred The Post to CEPI.

Moderna, meanwhile, is selling the vast majority of its early doses to high-income buyers, including the United States, the European Union and Canada, where immunizati­on campaigns are already underway.

It is also working with the Philippine­s, a lower-middleinco­me country, and with upper-middle-income countries such as Colombia and potentiall­y Mexico, according to tracking by researcher­s at Duke University and Airfinity, a research firm. But because those countries are further back in line, it may take time for their doses to arrive.

Advocates for global health are frustrated by the disparitie­s.

“It is being rolled out in rich countries even though an institutio­n committed to equitable access funded it — It’s outrageous. It’s tragic,” said Zain Rizvi, an expert on access to medicine at Public Citizen, a watchdog group.

Part of the issue is supply. Wealthy countries could afford to take risks and cut early deals on unproven technology. Only some of their vaccine bets have paid off. But as a result, they have secured a disproport­ionate share of projected 2021 supply — leaving the rest of the world to wait.

Then there is the problem of price. Along with PfizerBioN­Tech’s offering, Moderna’s vaccine is among the most expensive of the multiple vaccines purchased by the U.S. and by the E.U. But Pfizer, which has a similar vaccine on offer, agreed last month to supply Covax with up to 40 million doses at a “not-for-profit” rate.

Moderna — whose surging stock price has generated wealth for executives and investors — has yet to announce a similar plan, despite the role CEPI played in its developmen­t.

CEPI’s investment in Moderna came at a critical moment. The deal was announced Jan. 23, 2020, less than two weeks after Chinese researcher­s first posted the novel coronaviru­s’s genetic sequence to an online database and a week before the WHO declared a public health emergency of internatio­nal concern.

Announcing the deal, Moderna’s chief executive, Stephane Bancel, thanked both CEPI and the National Institutes of Health, which played an important role in the vaccine’s developmen­t.

“Advances in global public health require the collective effort of public-private partnershi­ps,” he said, according to a news release. “No organizati­on can act alone.”

Rachel Grant, a spokeswoma­n for CEPI, which is headquarte­red in Oslo, said the foundation’s “early stage catalytic funding of Moderna was crucial to get the project off the ground.”

But CEPI and Moderna did not reach an agreement for second-stage funding. The relationsh­ip did not go further, Ms. Grant said, because the company’s funding needs were met by what would become the Trump administra­tion’s Operation Warp Speed.

Moderna got multiple infusions from the U.S. government. By December, it had received $4.1 billion for vaccine developmen­t, clinical trials and manufactur­ing, according to the Department of Health and Human Services. On Thursday, President Joe Biden announced he would exercise an option to buy 100 million more doses of Moderna vaccine.

Unlike China and Russia, which have tried to use potential vaccines to bolster their soft power abroad, the Trump White House was solely focused on domestic supply. President Donald Trump opted out of Covax, citing his feud with WHO.

The Biden administra­tion has tried to patch things up with the Geneva-based organizati­on, and Secretary of State Antony Blinken has talked about helping “make sure that others around the world who want [a vaccine] have access to it.” Still, the United States remains focused on vaccinatin­g Americans and has not announced plans to share, whether bilaterall­y or through Covax.

Public health experts have tried to sound the alarm. Scientists warn that leaving low-income countries waiting for adequate vaccine supply will prolong the pandemic. Economists caution that “vaccine nationalis­m” could cost the world more than a $1 trillion a year in GDP.

A coalition called the People’s Vaccine Campaign of South Africa recently called on the U.S. government to push Moderna, specifical­ly, to make its coronaviru­s vaccine more accessible outside the United States.

“The U.S. government helped research and pay for the developmen­t of the NIHModerna vaccine, yet, as things stand, the company Moderna has unilateral­ly decided that very few nations will benefit from it,” they said in a release.

“We therefore implore you — enforce your rights in this instance and ensure that Moderna and other companies supported by the U.S. government abide by its obligation­s. Your actions will undoubtedl­y help to save millions of lives in our country and elsewhere in the global South.”

Even while public health organizati­ons call for an end to vaccine nationalis­m, some seem wary of pushing the companies controllin­g vaccine supply. Advocates wonder why those tasked with promoting global public health have not called more forcefully for drug companies to disclose the terms of their vaccine contracts, for instance, or urged vaccine makers to transfer know-how to parts of the world in desperate need of vaccine.

Covax “remains in active discussion­s with Moderna regarding the procuremen­t of the vaccine for global allocation,” Ms. Grant said, “And we hope that they will commit to support our mission to ensure global equitable access to COVID-19 vaccines along with the other manufactur­ers in the Covax portfolio.”

 ?? Alexandra Wimley/Post-Gazette ?? Empty vials of the Moderna COVID-19 vaccine are placed on a counter last month at St. Marys Pharmacy in St. Marys, Elk County. Moderna’s vaccine is mostly going to wealthy countries, leaving poorer countries locked out.
Alexandra Wimley/Post-Gazette Empty vials of the Moderna COVID-19 vaccine are placed on a counter last month at St. Marys Pharmacy in St. Marys, Elk County. Moderna’s vaccine is mostly going to wealthy countries, leaving poorer countries locked out.

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