IS YOUR BLADDER ALWAYS TAKING YOU ON A TRIP OF ITS OWN?

In clinical trials, those taking Myrbetriq made fewer trips to the bathroom and had fewer leaks than those not taking Myrbetriq. Your results may vary.

*Based on 24-month TRX shares for all branded OAB medications, IMS Health National Prescription Audit, January 2019–December 2020. THIS INFORMATION DOES NOT IMPLY SAFETY OR EFFICACY OF ANY PRODUCT; NO COMPARISONS SHOULD BE MADE.

USE OF MYRBETRIQ

MYRBETRIQ® (mirabegron extended-release tablets) is a prescription medicine for adults used to treat overactive bladder (OAB) with symptoms of urgency, frequency and leakage.

IMPORTANT SAFETY INFORMATION

Do not take MYRBETRIQ if you are allergic to mirabegron or any ingredients in MYRBETRIQ. MYRBETRIQ may cause your blood pressure to increase or make your blood pressure worse if you have a history of high blood pressure. You and your doctor should check your blood pressure while you are taking MYRBETRIQ. Call your doctor if you have increased blood pressure.

MYRBETRIQ may increase your chances of not being able to empty your bladder. Tell your

IMPORTANT SAFETY INFORMATION (continued)

doctor right away if you have trouble emptying your bladder or you have a weak urine stream. MYRBETRIQ may cause an allergic reaction with swelling of the face, lips, throat or tongue with or without difficulty breathing. Stop using MYRBETRIQ and go to the nearest hospital emergency room right away.

Tell your doctor about all the medicines you take including medications for overactive bladder or other medicines especially thioridazine (Mellaril™ and Mellaril-s™), flecainide (Tambocor®), propafenone (Rythmol®), digoxin (Lanoxin®) or solifenacin succinate (Vesicare®). MYRBETRIQ may affect the way other medicines work, and other medicines may affect how MYRBETRIQ works. Before taking MYRBETRIQ, tell your doctor about all of your medical conditions, including if you have liver or kidney problems.

The most common side effects of MYRBETRIQ include high blood pressure, pain or swelling of the nose or throat (nasopharyngitis), urinary tract infection, and headache.

For further information, please talk to your healthcare professional and see Brief Summary of Prescribing Information for Myrbetriq® (mirabegron extended-release tablets) on the following pages.

You are encouraged to report negative side effects of prescription drugs to the FDA.

Visit www.fda.gov/medwatch or call 1-800-FDA-1088.