Richmond Times-Dispatch

BritainOKs­Pfizer vaccine, will begin shotswithi­n days

It’s the first nation to reach key milestone in race to end pandemic

- BY LAURAN NEERGAARD AND DANICA KIRKA

LONDON— Britain became the first country in the world to authorize a rigorously tested COVID-19 vaccine Wednesday and could be dispensing shots within days — a historic step toward eventually ending the outbreak that has killed more than 1.4 million people globally.

In giving the go-ahead for emergency use of the vaccine developed by American drugmaker Pfizer and Germany’s BioNTech, Britain vaulted past the United States by at least a week. The U.S. Food and Drug Administra­tion is not scheduled to consider the vaccine until Dec. 10.

“This is a day to remember, frankly, in a year to forget,” British Health Secretary Matt Hancock said.

The announceme­nt sets the stage for the biggest vaccinatio­n campaign in British history and came just ahead of what experts are warning will be a long, dark winter, with the coronaviru­s surging to epic levels in recent weeks in the U.S. and Europe.

Officials cautioned that several tough months still lie ahead even in Britain, given the monumental task of inoculatin­g large swaths of the population. Because of the limited initial supply, the first shots will be reserved for those most in danger, namely nursing home patients, the elderly and health care workers.

Britain’s Medicines and Healthcare Products Regulatory Agency recommende­d the vaccine after clinical trials involving tens of thousands of volunteers showed it was 95% effective and turned up no serious side effects. The vaccine

is still considered experiment­al while final testing is done.

“This is an unpreceden­ted piece of science,” given that the vaccine was authorized less than a year after the virus was discovered, said David Harper, senior consulting fellow in global health at the Chatham House think tank.

Prime Minister Boris Johnson declared that the “searchligh­ts of science” had picked out the “invisible enemy,” which has been blamed for close to 60,000 deaths in Britain. He said that in developing the vaccine, scientists had performed “biological jujitsu” by turning the virus on itself.

Other countries aren’t far behind: Regulators not only in the U.S. but in the European Union and Canada also are vetting the Pfizer vaccine along with a shot made by Moderna. British and Canadian regulators are also considerin­g a vaccine made by AstraZenec­a and Oxford University.

Amid growing concern in the U.S. that Americans will greet vaccines with skepticism, U.S. Health and Human Services Secretary Alex Azar said Britain’s decision “should give Americans additional confidence in the quality of such a vaccine.” The virus has killed more than 270,000 in the U.S.

Hancock said Britain will begin receiving the first shipment of 800,000 doses from Belgium within days, and people will start getting the shots as soon as it arrives. Two doses three weeks apart are required. The country expects to receive millions of doses by the end of this year, Hancock said, though the exact number will depend on how fast it can be manufactur­ed and checked for quality.

BioNTech, which owns the vaccine, said it has so far signed deals to supply 570 million doses worldwide in 2021, with options to deliver 600 millionmor­e. It hopes to supply at least 1.3 billion in 2021.

That is only a fraction of what will be needed as public health officials try to vaccinate much of the world’s population. Experts have said several vaccines will be required to quickly end the pandemic that has infected more than 64 million people globally.

In Britain, the first shots will go to nursing home patients and those who care for them, followed by everyone over 80 and health care workers. From there, the program will be expanded as the supply increases, with the vaccine offered roughly on the basis of age groups, starting with the oldest people.

Amid the burst of optimism, Pfizer CEO Albert Bourla warned government­s against any immediate move to relax restrictio­ns and reopen their economies.

“The time that we will have to go back to normality is not far away,” he said. “But it is definitely not now.”

Despite the speed with which they approved the vaccine, and the intense political pressure surroundin­g the worldwide race to solve the crisis, British regulators insisted “no corners have been cut” during the review process.

Hours after Britain’s announceme­nt, Russian President Vladimir Putin, not to be outdone, ordered the start of a largescale COVID-19 vaccinatio­n campaign by late next week, with doctors and teachers to be first in line to receive the shot.

The standard 14-day coronaviru­s quarantine­s potentiall­y can be shortened to 10 days or even seven, according to revised guidance issued Wednesday by the Centers for Disease Control and Prevention in an effort to boost compliance with one of the most important tools for limiting spread of the virus.

The move reflects the agency’s recognitio­n that the two-week quarantine rule is onerous for many people and that most of the public health benefit from quarantini­ng people exposed to the virus can be gained with a more flexible approach.

The CDC acknowledg­es that this new guidance involves a trade-off. The existing 14-day recommenda­tion reflects the ability of the virus to incubate for a long period before symptoms appear. But lack of compliance can undermine the public health benefit from that standard.

CDC officials also announced new guidance for testing before and after traveling: Someone planning a trip should get a test one to three days in advance and then be tested again three to five days after returning. And the agency reiterated its pre-Thanksgivi­ng recommenda­tion against travel this holiday season amid a massive spike in coronaviru­s infections nationwide that is filling hospitals with covid-19 patients and claiming on average of more than 1,500 lives every day.

 ?? THE ASSOCIATED PRESS ?? Britain’s approval of the Pfizer-BioNTech vaccine set the stage for the biggest vaccinatio­n campaign in the nation’s history.
THE ASSOCIATED PRESS Britain’s approval of the Pfizer-BioNTech vaccine set the stage for the biggest vaccinatio­n campaign in the nation’s history.

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