Richmond Times-Dispatch

Vaccine nod

Pfizer treatment endorsed by U. S. panel.

- BY LAURAN NEERGAARD AND MATTHEW PER R ONE

WASHINGTON— A U.S. government advisory panel endorsed widespread use of Pfizer’s coronaviru­s vaccine Thursday, putting the country just one step away from launching an epic vaccinatio­n campaign against the outbreak that has killed close to 300,000 Americans.

Shots could begin within days, depending on how quickly the Food and Drug Administra­tion signs off, as expected, on the expert committee’s recommenda­tion.

In a 17-4 vote with one abstention, the government advisers concluded that the vaccine from Pfizer and its German partner BioNTech appears safe and effective for

emergency use in adults and teenagers 16 and older.

That endorsemen­t came despite questions about allergic reactions in two people who received the vaccine earlier this week when Britain became the first country to begin dispensing the

Pfizer-BioNTech shot.

Despite all the remaining unknowns, in an emergency, “the question is whether you know enough,” said panel member Dr. Paul Offit of Children’s Hospital of Philadelph­ia, who concluded that the shot’s potential benefits outweigh its risks.

The independen­t review by non-government experts in vaccine developmen­t, infectious diseases and medical statistics was considered critical to boosting Americans’ confidence in the safety of the shot, which was developed at breakneck speed less than a year after the virus was identified.

The decision came as COVID-19 cases surge to ever-higher levels across the U.S., with deaths hitting an all-time, one-day high of more than 3,100 on Wednesday.

Pfizer has said it will have about 25 million doses of the two-shot vaccine for the U.S. by the end of December. But the initial supplies will be reserved primarily for health care workers and nursing home residents, with other vulnerable groups next in line until ramped-up production enables shots to become

widely available on demand— something that will probably not happen until the spring.

The FDA next week will review a second vaccine, from Moderna and the National Institutes of Health, that appears about as protective as Pfizer-BioNTech’s shot.

A third candidate, from Johnson & Johnson, which would require just one dose, is working its way through the pipeline. Behind that is a candidate from AstraZenec­a and Oxford University.

U.S. health experts are hoping a combinatio­n of vaccines will ultimately enable the U.S. to conquer the outbreak.

But experts estimate at least 70% of the U.S. population will have to be vaccinated to achieve herd immunity, the point at which the virus can be held in check. That means it could be several months before things start get back to normal and Americans can put away their masks.

All eyes now turn to the FDA staff scientists who will make the final decision on whether to press ahead with widespread use of the Pfizer-BioNTech vaccine. FDA’s vaccine director Dr. Peter Marks said ahead of the expert meeting that a decision would come within “days to a week.”

Regulators not only in Britain but in Canada have already approved the vaccine for use in their countries, and President Donald Trump and White House officials have complained for weeks about

the pace of FDA’s careful review.

“Americans want us to do a scientific review, but I think they also want us to make sure we’re not wasting time on paperwork as opposed to going forward with the decision,” FDA Commission­er Stephen Hahn said before the meeting.

A positive vote for the vaccine was virtually assured after FDA scientists issued a glowing review of the vaccine earlier in the week. Agency staffers said data from Pfizer’s ongoing study of 44,000 people showed strong protection across different age groups, races and health conditions with no major, unexpected safety problems.

The Pfizer-BioNTech shot remains experiment­al because that final-stage study isn’t complete. As a result, the expert panel wrestled with a list of questions that have yet to be answered.

For example, while the vaccine is more than 90% effective in blocking the symptoms of COVID19, the FDA’s advisers stressed it is not yet clear whether it can stop the silent, symptomles­s spread that accounts for up to half of all cases.

“Even though the individual efficacy of this vaccine is very, very, very high, you really as of right now do not have any evidence” that it will lower transmissi­on, said Dr. Patrick Moore of the University of Pittsburgh. He urged Pfizer to take additional steps to answer that question.

The advisers worried, too, that Pfizer will lose its opportunit­y to answer critical questions as it begins offering the real vaccine to study participan­ts who had been getting dummy shots up to now.

The company proposed gradually moving those patients to the vaccine group, with priority based on age, health conditions and other factors. Under that plan, 70-yearold participan­ts would cross over before healthy 30-year-olds.

Pfizer must still show whether the vaccine works in children younger than 16 and in pregnant women.

On the safety

front, as widespread vaccinatio­ns begin, the first recipients will be closely tracked by government health authoritie­s since studies in tens of thousands of people can’t detect rare risks that strike 1 in a million.

Hanging over the meeting were the British allergic reactions and a warning from authoritie­s there that people with a history of serious reactions shouldn’t get the vaccine for now.

Pfizer representa­tives said they have seen no signs of allergic reactions in their trial. But some of the FDA advisers fear the British warning will deter millions of Americans with allergies who might benefit from the COVID19 vaccine from giving it a try, and urged additional studies to try to settle the issue.

“This issue is not going to die until we have better data,” Offit said.

 ?? PHOTOS BY THE ASSOCIATED PRESS ?? An example of the Pfizer COVID-19 vaccine vial is visible on a desk before FedEx executive Richard Smith (left), andWesley Wheeler with United Parcel Service during a Senate Transporta­tion subcommitt­ee hybrid hearing Thursday on transporti­ng a coronaviru­s vaccine. Pfizer’s vaccine cleared another key hurdle Thursday, and shots could begin in days.
PHOTOS BY THE ASSOCIATED PRESS An example of the Pfizer COVID-19 vaccine vial is visible on a desk before FedEx executive Richard Smith (left), andWesley Wheeler with United Parcel Service during a Senate Transporta­tion subcommitt­ee hybrid hearing Thursday on transporti­ng a coronaviru­s vaccine. Pfizer’s vaccine cleared another key hurdle Thursday, and shots could begin in days.
 ??  ?? A pharmacist labels syringes in a clean room where doses of COVID-19 vaccines will be handled at Mount Sinai Queens hospital in NewYork. The hospital expects to receive doses once a vaccine gets the green light by U.S. regulators.
A pharmacist labels syringes in a clean room where doses of COVID-19 vaccines will be handled at Mount Sinai Queens hospital in NewYork. The hospital expects to receive doses once a vaccine gets the green light by U.S. regulators.
 ??  ?? FDA Commission­er Dr. Stephen Hahn testified Thursday in the Senate.
FDA Commission­er Dr. Stephen Hahn testified Thursday in the Senate.

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