San Antonio Express-News (Sunday)

Getting shots to rural areas is a challenge

- By Bennett Doughty and Pamela Stewart Fahs Doughty is a clinical assistant professor of pharmacy practice and Stewart Fahs is a professor of rural Nursing, both at Binghamton University, State University of New York.

The enormous job of vaccinatin­g the nation is underway, but for rural Americans, getting a COVID-19 vaccine becomes harder the farther they are from urban centers.

The current vaccines’ cold storage requiremen­ts and shipping rules mean many rural hospitals can’t serve as vaccinatio­n distributi­on hubs. That can leave rural residents — about 20 percent of the U.S. population — traveling long distances, if they’re able to travel at all.

Getting the word to rural residents about when they can be vaccinated isn’t easy either, and the extraordin­ary amount of misinforma­tion downplayin­g the risk of the coronaviru­s has had an impact on rural residents’ willingnes­s to get the vaccine.

We work in rural health care settings and have been examining the barriers to health care for these patients to find ways to ensure health and safety.

Storage problems

The first two authorized vaccines — one made by Pfizer and BioNTech and the other by Moderna — are mRNA vaccines. It’s a new type of vaccine that uses the molecular instructio­ns for building virus proteins rather than injecting parts of the weakened virus itself. Both must be kept in very cold temperatur­es.

To ensure stability, the vaccine doses are shipped in special containers with dry ice, and for now, vaccines are being delivered only in large batches.

The Pfizer vaccine is shipped in increments of 975 doses, which creates a challenge for small hospitals. Urban areas will be able to quickly distribute those doses, but finding enough patients to vaccinate quickly in rural areas may prove more difficult. Moderna’s vaccine is somewhat more manageable, with a minimum order of 100 doses.

Both vaccines also require two doses per person, with the second dose of Pfizer’s vaccine given 21 days later and Moderna’s 28 days later. As a result, the vaccine distributi­on efforts will favor hubs that cater to more populated areas to avoid wasting any vaccine or leaving patients unable to get their second dose.

Cold storage is another challenge, since small hospitals are

less likely to have expensive freezers. The Pfizer vaccine must be stored at minus 94 degrees and Moderna’s at minus 4 degrees. There are limits on how many times the vaccine shipping containers can be opened and how quickly the vaccines must be distribute­d. Once thawed and prepared, the Pfizer vaccine must be used within five days and Moderna’s within 30 days.

Each patient must receive both doses of the vaccine from the same manufactur­er to ensure safety and effectiven­ess, adding to the challenge. Manufactur­ers have included personal dosing cards for patients to carry with them to help.

Rural America’s take

Rural America already has difficult barriers to health care access. It has fewer health care providers serving a more geographic­ally diverse population than in metropolit­an communitie­s. And in many of these areas, rural hospitals have been closing at an alarming rate, leaving people to travel farther for care.

The population is also older. Public transporta­tion that could help poor or elderly residents reach hospitals is rare, and distance and geography, such as mountain roads, can mean driving to those sites takes time.

Getting accurate informatio­n

about the vaccine and how to receive it into rural areas has also proven difficult. Many rural counties still have limited access to broadband internet connection­s, smartphone service and other technologi­es. That often means residents rely on television, newspapers and radio for news, which can limit the depth and scope of informatio­n.

While some rural counties have started getting the word out, many don’t seem to have specific plans on how to inform

their residents about how and when each person can get the vaccine, let alone specific plans for actually giving it. They often rely just on local press releases that many residents never see.

Rural nonprofit health care organizati­ons have tried to bridge that gap and improve rural communicat­ions about vaccines and the pandemic. Care Compass Network, which coordinate­s organizati­ons across southern New York, has offered educationa­l webinars with the latest informatio­n about the virus and the vaccines, for example. But there is still much work to do.

Rural Americans’ views on vaccines are influenced by media and word of mouth, politics and religion, as well as previous experience with vaccinatio­ns and, perhaps most importantl­y, the difficulty of accessing health care.

In a survey conducted by the Kaiser Family Foundation in December, about 35 percent of rural Americans said they probably or definitely would not get the vaccine, higher than the 27 percent nationwide.

Small batches, new vaccines

Getting enough of the U.S. vaccinated to eventually end the pandemic will require more work in all of these areas. That includes improving shipping and storage processes so orders can be broken up and distribute­d to smaller hospitals, distributi­ng more vaccine doses, and improving communicat­ion.

With Moderna’s vaccine arriving in smaller batches and not requiring such low temperatur­es for stability, it may prove to be more accessible for rural areas. Utah has already taken advantage of those characteri­stics to get initial doses to smaller hospitals and has started vaccinatin­g health care providers. Pfizer has said it may be able to offer smaller batches by April.

Other vaccines on the horizon are also expected to have less stringent storage requiremen­ts and may potentiall­y be delivered in one shot. The British government on Dec. 30 authorized one of them, a two-dose vaccine developed by the University of Oxford and AstraZenec­a that can be stored in a normal refrigerat­or for six months. U.S. officials are awaiting more testing on it, however, and don’t expect authorizat­ion for U.S. use until April.

The falling number of rural hospitals also remains a challenge for getting vaccines to patients. Allowing community pharmacies to offer the vaccine — particular­ly if independen­t pharmacies are included — could eventually help expand the distributi­on network in rural areas.

 ?? Ronny Hartmann / AFP via Getty Images ?? The currently available COVID-19 vaccines require storage in an ultra-low freezer, which many rural communitie­s may not have since small hospitals are less likely to have expensive freezers.
Ronny Hartmann / AFP via Getty Images The currently available COVID-19 vaccines require storage in an ultra-low freezer, which many rural communitie­s may not have since small hospitals are less likely to have expensive freezers.
 ?? WPA Pool / Getty Images ?? A vaccine developed by the University of Oxford and AstraZenec­a can be stored in a normal refrigerat­or for six months.
WPA Pool / Getty Images A vaccine developed by the University of Oxford and AstraZenec­a can be stored in a normal refrigerat­or for six months.

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