San Francisco Chronicle

How psychedeli­c drugs have altered modern medicine.

- By April M. Short April M. Short is a freelance writer.

The old hippie adage, “Turn on, tune in, drop out,” now comes with a modern addendum: “Get federal funding.”

This weekend marks the 50th anniversar­y of the Human Be-In, the historic drug policy protest that attracted tens of thousands of people to San Francisco in 1967 and served as the catalyst for the Summer of Love. It also spurred the radical ascension of psychedeli­c science research into mainstream medicine.

The Human Be-In sparked a cultural paradigm shift unrivaled since World War II, and despite a conservati­ve backlash and decades-long prohibitio­n, psychedeli­cs are inexorably moving from the Polo Fields of Golden Gate Park into the therapist’s office.

Federal research dollars now flow into studies that give marijuana and MDMA, or ecstasy, to post-traumatic stress disorder (PTSD) sufferers, and the hallucinog­ens LSD and psilocybin to cancer patients with depression and anxiety. And the drugs work, modern studies show.

“These ideas became so embedded in our own culture, we don’t even sometimes remember that they were once radical ideas pushed forward by a group of young people who gathered in a neighborho­od,” said Haight-Ashbury resident Annie Oak, founder of feminist psychedeli­cs nonprofit Women’s Visionary Congress.

For thousands of years, humans have used plantderiv­ed drugs to alter their consciousn­ess for therapy and spirituali­ty. In the modern era, the potent hallucinog­en LSD was first created by Swiss chemist Albert Hoffman in 1938, and became a candidate for psychother­apeutic uses by 1950.

Researcher­s used LSD to treat depression and alcoholism until 1962, becoming the focus of more than 1,000 published studies and cultural buzz. Then the Federal Drug Administra­tion began restrictin­g such research and as use spread, especially among youth, California lawmakers feared for public safety. On Oct. 6, 1966, the state banned LSD, sparking several protests, including the Be-In.

President Richard Nixon’s war on drugs vilified psychedeli­cs and cannabis. By 1970, federal officials ranked those drugs among the most dangerous, and research nearly stopped. Marijuana and most psychedeli­cs remain federally illegal to this day, but researcher­s have persevered.

Much of the progress they have made is the result of more than 30 years of effort by the Multidisci­plinary Associatio­n for Psychedeli­c Studies, or MAPS, a Bay Area nonprofit founded by Rick Doblin in 1986. Doblin has a doctorate in public policy from Harvard’s Kennedy School of Government, where he wrote his dissertati­on on the regulation of the medical uses of psychedeli­cs and marijuana.

Since the Be-In, “marijuana has gone from being a heavily demonized drug used by rebellious youth to a medicine with one of the largest growing demographi­cs being elderly people,” said Doblin.

Psychedeli­cs have taken a similar path. “Research was virtually eliminated across the world, and now (psychedeli­cs) are being investigat­ed as tools used in scientific research for therapeuti­c uses, a catalyst of spirituali­ty, art and creativity, acceptance of death, and we are now facing their legitimiza­tion and acceptance as medical tools,” Doblin said.

Since about 2000, private and internatio­nal teams have revamped the study of psychedeli­cs, mostly with private funding. California and seven other states have legalized cannabis for adult use, generating tens of millions of tax dollars earmarked for research that otherwise would not be performed.

Doblin thinks psychedeli­cs will follow the route of cannabis — first accepted medicinall­y, then more broadly.

Today, the first U.S. government-approved human trials assessing psychedeli­cs in tandem with psychother­apy treatment are yielding positive results. Psychedeli­cs can alter brain function just long enough to gain lasting, new perspectiv­es on crippling fears and traumas, according to researcher­s.

For most of these studies, participan­ts with a chronic, intractabl­e psychologi­cal issue, such as PTSD, are given a placebo or controlled dose of a psychedeli­c, say MDMA. Patients then take part in a guided therapy session. The results so far show unpreceden­ted success and safety across the board.

MAPS is on track to make MDMA a legal medicine, in tandem with therapy, to treat severe post-traumatic stress and anxiety by 2020. The group has also sponsored other breakthrou­gh studies with results pointing to the potential of MDMA, LSD, psilocybin and other drugs to help a variety of severe, treatment-resistant mental health conditions.

“The future of psychedeli­cs in our society is bright — a thousand points of light,” Doblin said. “The integratio­n of psychedeli­cs into health care practices could not come at a better time for America, when healing and understand­ing are desperatel­y needed.”

Bill McCarthy, founder of the Unity Foundation and co-producer of Saturday’s Human Be-In 50th Anniversar­y celebratio­n, said the current political climate makes events like the Be-In more relevant than ever.

“If we take that long view, bringing it back to ’67 and forward until now, and we see all the changes, movements, breakthrou­ghs,” he said, “how can we be afraid?”

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