Week 6 Panthers (3-2) at Buccaneers (2-3)

Last week vs. the spread: 7-8. Season: 38-39-1.

9:30 a.m. Sunday | Panthers by 2 | O/U 47 Everything with the Panthers runs through Christian McCaffrey, but no one seems to be able to run through this Bucs defense. The Bucs do enough to protect Jameis Winston.

Buccaneers 28, Panthers 23

Bengals (0-5) at Ravens (3-2)

1 p.m. Sunday | Ravens by 11 | O/U 48

No wonder the Bengals are winless. They can’t stop the pass or the run. Ravens QB Lamar Jackson will wear down when he’s running at this rate, but he can do this against the Bengals.

Ravens 24, Bengals 17

Saints (4-1) at Jaguars (2-3)

1 p.m. Sunday | Jaguars by 21⁄ | O/U 43 2

The Jaguars crumbled under the weight of the Panthers’ run game. That’s good news for Alvin Kamara. Teddy Bridgewater showed last week that he’s more than just a game manager.

Saints 27, Jaguars 20

Texans (3-2) at Chiefs (4-1)

1 p.m. Sunday | Chiefs by 4 | O/U 55

The Chiefs are going to try to keep the ball in front of them and make Deshaun Watson nickel and dime them. The Chiefs offense is next level no matter who’s in.

Chiefs 34, Texans 27

Seahawks (4-1) at Browns (2-3)

1 p.m. Sunday | Seahawks by 1 | O/U 46

The Browns were embarrassed against the run last week and now face a team that loves to grind it out on the ground. And when the Seahawks don’t run, there’s Russell Wilson.

Seahawks 27, Browns 17

Redskins (0-5) at Dolphins (0-4)

1 p.m. Sunday | Redskins by 4 | O/U 42

Two horrendous teams. Give the edge to the Redskins because of the fleeting surge that often follows a coaching change and the fact they’re playing the historically bad Dolphins.

Redskins 24, Dolphins 20

Eagles (3-2) at Vikings (3-2)

1 p.m. Sunday | Vikings by 3 | O/U 44

Great matchup. This is the biggest test yet for Dalvin Cook and the Vikings’ excellent ground game. Here’s betting he does just enough to free up opportunities for Kirk Cousins at home.

Vikings 23, Eagles 21

Falcons (1-4) at Cardinals (1-3-1)

4:05 p.m. Sunday | Falcons by 21⁄ | O/U 511⁄

2 2 The Cardinals are riding high-ish after their first victory, but they, like the Falcons, are still a one-win team. Give the edge to Matt Ryan going against a vulnerable defense.

Falcons 27, Cardinals 24

49ers (4-0) at Rams (3-2)

4:05 p.m. Sunday | Rams by 3 | O/U 50 1⁄2

The Rams have had extra time to think about their back-to-back losses. They lost in Seattle but played their most complete game. They do enough at home to slow the 49ers’ roll.

Rams 27, 49ers 23

Titans (2-3) at Broncos (1-4)

4:25 p.m. Sunday | Broncos by 2 | O/U 401/ 2 The Titans defense has struggled against the run. That opens the door for the one-two punch of Phillip Lindsay and Royce Freeman.

Broncos 23, Titans 18

Cowboys (3-2) at Jets (0-4)

4:25 p.m. Sunday | Cowboys by 7 | O/U 44 1⁄2 Dak Prescott has been a missing person the last two games, but playing the Jets is like a successful trip to the lost-and-found.

Cowboys 31, Jets 23

Steelers (1-4) at Chargers (2-3)

8:20 p.m. Sunday | Chargers by 61⁄ | O/U 411⁄

2 2 Maybe Devlin Hodges will surprise everyone if Mason Rudolph (concussion) can’t play, but that’s a big ask of an undrafted rookie.

Chargers 31, Steelers 17

Lions (2-1-1) at Packers (4-1)

8:15 p.m. Monday | Packers by 4 | O/U 45 Matchup is all about Aaron, but it’s not just Aaron Rodgers. The Packers have found balance with Aaron Jones.

Packers 27, Lions 24