DOLPHINS (1-4) at JAGUARS (0-5)

Kickoff: 9:30 a.m., Tottenham Hotspur Stadium, London TV: CBS (Chs: 4 in Miami-Dade/Broward and 12 in Palm Beach); RADIO: WQAM (560 AM), KISS (99.9 FM), WQBA (1140 AM, Spanish)

Coaches: Brian Flores is 16-21 in his third season with Dolphins; Urban Meyer is 0-5 in his first season leading the Jaguars.

Series: The Dolphins and Jaguars are tied, 5-5, in the all-time series, including the lone playoff meeting that went to Jacksonville.

Line: The Dolphins are a 3-point favorite; the over/under is 47.

Injuries: Dolphins — Out: CB Xavien Howard (shoulder/ groin), WR DeVante Parker (shoulder/hamstring); Questionable: QB Tua Tagovailoa (ribs), CB Byron Jones (Achilles/groin), WR Preston Williams (groin), QB Jacoby Brissett (hamstring), TE Adam Shaheen (knee); Injured reserve: WR Will Fuller (finger), C Michael Deiter (foot/ quad), WR Lynn Bowden (hamstring), WR Allen Hurns (wrist), T Larnel Coleman (knee); Jaguars — Out: LB Myles Jack (back), OL Rashaad Coward (ankle);

Questionable: CB Tyson Campbell (toe), DL Roy Robertson (ankle); Injured reserve: G A.J. Cann (knee); WR D.J. Chark (ankle), RB Travis Etienne (foot), WR Terry Godwin (undisclosed), C Brandon Linder (knee), TE James O’Shaughnessy (ankle)

Noteworthy: Something’s got to give. The Dolphins come in on a four-game losing streak with an average margin of defeat of 15 this season. The Jaguars are winless this season, haven’t won since Week 1 of 2020 and come in with an average margin of defeat of 12 this year. ... Quarterback Tua Tagovailoa is expected to make his return after three weeks on injured reserve for fractured ribs. He gets to face Jaguars rookie Trevor Lawrence in their first matchup since the college national championship game following the 2018 season, which Lawrence’s Clemson Tigers won, 44-16. ... The Dolphins play in Tottenham Hotspur Stadium for the first time. Their four previous trips to London (1-3) were games played at Wembley Stadium. ... Jacksonville cornerback Shaquill Griffin and Dolphins practice squad linebacker Shaquem Griffin are twin brothers.