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Modified pests may be used in Zika fight

- By Jamey Keaten and Maria Cheng Associated Press

GENEVA — The World Health Organizati­on said it may be necessary to use controvers­ial methods like geneticall­y modified mosquitoes to wipe out the insects that are spreading the Zika virus across the Americas.

Thevirus has been linked to a spike in babies born with abnormally small heads, or microcepha­ly, in Brazil and French Polynesia. The U.N. health agency has declared Zika a global emergency, even though there isno definitive proof it is causing the birth defects.

WHO said its advisory group has recommende­d further field trials of geneticall­y modified mosquitoes, which have previously been tested in small trials in the Cayman Islands andMalaysi­a.

“Given the magnitude of the Zika crisis, WHO encourages affected countries … to boost the use of both old and new approaches to mosquito control as the most immediate line of defense,” WHOsaid in a statement. WHO said at least 34 countries have been hit by the virus in the current crisis, mostly in Latin America.

WHO said previous experiment­s that released sterile insects have been used by other U.N. agencies to control agricultur­al pests. The agency described the Aedes aegypti mosquitoes that spread Zika— aswell as other diseases including dengue and yellow fever — as an “aggressive” mosquito that uses “sneak attacks” to bite people, noting that the mosquito has shown “a remarkable ability to adapt.”

Last month, British biotech firm Oxitec said tests in Brazil in 2015 showed that geneticall­y altered sterile male mosquitoes succeeded in reducing a type of diseasemos­quito larvae by 82 percent in one neighborho­od in the city of Piracicaba. The geneticall­y modified males don’t spread disease because only female mosquitoes bite.

Environmen­talists have previously criticized the geneticall­y modified approach, saying wiping out an entire population of insects co-=uld have unforeseen knock-on effects on the ecosystem.

Some experts agreed it might be worth using geneticall­y tweaked mosquitoes given the speed of Zika’s spread.

“The way this is done wouldn’t leave lots of mutant mosquitoes in the countrysid­e,” said Jimmy Whitworth, an infectious diseases expert at the London School of Hygiene and Tropical Medicine. He said the Zika mosquitoes are an imported species that were accidental­ly brought to the Americas hundreds of years ago, and he was optimistic their eradicatio­n wouldn’t damage the environmen­t.

However, he said such a move would be unpreceden­ted and it would be impossible to know what the impact might be before releasing the insects into the wild.

“Youwould hope that the ecologywou­ld just return to how it was before this mosquito arrived,” he said. “But there’s no way of knowing that for sure.”

 ?? PERCIO CAMPOS/EPA ?? Brazil’s military fans out in a push to kill potential breeding places for the mosquito-borne Zika virus Tuesday in Recife.
PERCIO CAMPOS/EPA Brazil’s military fans out in a push to kill potential breeding places for the mosquito-borne Zika virus Tuesday in Recife.

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