The Arizona Republic

What is inflammati­on, and why should I care?

- Dr. Mehmet Oz and Dr. Michael Roizen

Here’s a short course in inflammati­on and how you can help put out the destructiv­e fire that may be glowing inside you.

Acute, short-term inflammati­on is your friend: It signals that your immune system has been called into action to fight off invading viruses and bacteria (or to help heal an injury). Here’s the drill: Sentinel cells, the guys at the guardhouse, alert your immune system when invaders appear. Then other cells cause your capillarie­s to leak blood plasma; its function is to envelop and slow down the invaders. Next, macrophage­s release cytokines. These are germ fighters that are then joined by your B- and T-cells, which KO the invaders. And then, when the hordes are vanquished, more cytokines are released that signal the battle is over and your immune soldiers can head back to their barracks.

Chronic inflammati­on causes disease instead of fighting it. It turns out that for a variety of reasons, the body can get caught in a state of persistent low-level inflammati­on. When that happens, your immune-system warriors cruise around your body even when there is no bacteria to fight off or injury to heal. Without specific targets to attack, they begin to damage organs, nerves and arteries.

They can interfere with how the body uses insulin, and that can lead to chronic-inflammato­ry conditions like Type 2 diabetes, heart disease and gastrointe­stinal woes. Chronic inflammati­on also is implicated in causing the tangle of amyloid plaques associated with Alzheimer’s disease, and rogue inflammato­ry cells produce free radicals that cause genetic mutations leading to cancer and feed the growth of tumors.

What causes chronic inflammati­on? Obesity and a sedentary lifestyle are two identified culprits. Excess fat cells (particular­ly in the belly) trigger the slow and steady release of those inflammato­ry first responders, the cytokines.

In addition, chronic inflammati­on is stoked by a diet packed with inflammato­ry foods, such as red meats and added sugars and syrups; lack of exercise and sleep; environmen­tal assaults from air pollution; toxic chemicals; hormone disruptors; and the use of tobacco, marijuana, and hookah and vaping parlors.

Signs you have chronic inflammati­on

Are you all-over achy, often fatigued, have irregular poop (either constipati­on or diarrhea), bloating, high blood pressure, weight gain? These can be signs that your immune system has gone rogue. But for a surefire diagnosis, ask your doctor for a CRP-HS blood test.

Lifestyle changes to make

Opt for seven to nine servings of fresh fruits and veggies daily; get 900 mg of omega-3 DHA, aim for seven to eight hours of restful sleep nightly, get moving with both aerobic exercise (five days a week) and strength building (two days).

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