The Arizona Republic

Illness causing paralysis in kids puzzles experts

Rare, polio-like illness can paralyze children

- Ken Alltucker

Scientists are studying whether a rare but paralyzing illness that has afflicted scores of children this year is linked to a respirator­y virus that circulates in late summer and early fall.

Scientists are studying whether the rare but paralyzing illness that has afflicted scores of children this year is linked to a respirator­y virus that circulates in late summer and early fall.

The Centers for Disease Control and Prevention this week reported 386 cases of acute flaccid myelitis since August 2014. The illness mainly strikes children.

Cases are exceedingl­y rare; less than 1 in a million children are affected. But for a small number of children, the results are devastatin­g.

It can paralyze a child’s arms and legs. Some who are stricken need ventilator­s to breathe. It can also cause muscle weakness, slurred speech, and difficulty moving eyes and swallowing.

CDC officials have not identified what causes AFM.

It’s described as a polio-like illness, but each confirmed case has tested negative for polio virus.

A strain of a respirator­y virus called enteroviru­s has been detected in several cases, but federal health officials say they don’t have enough evidence to conclude a single culprit is responsibl­e for AFM. They also are investigat­ing whether genetic or environmen­tal factors are involved.

“This is a mystery so far, and we haven’t solved it yet,” said Nancy Messonnier, director of the CDC’s National Center for Immunizati­on and Respirator­y Diseases.

The illness peaks every other year from late summer to early fall. Public health officials began tracking it in 2014 with 120 cases in 34 states. There were fewer than two dozen cases in 2015, but the illness surged again in 2016, with 149 cases in 39 states.

So far this year, 62 cases are confirmed in 22 states, and another 65 suspected cases are being investigat­ed, according to the CDC.

Priya Duggal, a genetic researcher at the Johns Hopkins Bloomberg School of Public Health in Baltimore, is studying the illness.

“It seems to be cyclical – it’s every two years,” she said. “It’s pretty tragic to see these families and to talk to these parents and realize how much their lives have been upended.”

Duggal’s study of about 60 families compares the genetic profile of children and adults in families stricken with the illness. In some families, parents and siblings recovered quickly from minor cold-like symptoms, while one child was paralyzed.

Duggal is looking for genetic clues to why some children are susceptibl­e to the more severe effects of the disease.

Some researcher­s believe the illness may be linked to a strain of enteroviru­s called D68, which circulated widely in 2014 among children who went to hospitals with trouble breathing. The respirator­y virus is spread through coughing, sneezing and unwashed hands.

Children’s Hospital Colorado noticed that a subset of children infected with D68 outbreak in 2014 developed muscle weakness.

Since then, the hospital has been tracking both the D68 virus and AFM.

“We have seen an every-other-year pattern in late summer to early fall of a surge in cases in acute flaccid myelitis,” said Kevin Messacar, a pediatric infectious disease specialist at the hospital in Aurora. “It directly correlates with the time D68 has been circulatin­g at our institutio­n and reported by colleagues in other parts of the country.”

Messacar suspects the number of cases is likely higher than the confirmed total. Health profession­als are not required to notify authoritie­s when they encounter a case; reporting is voluntary.

To be confirmed as AFM, cases must meet a strict definition: signs of a weak or flaccid limb confirmed by MRI images of a patient’s spine.

If D68 continues to circulate every other year, Messacar said, public health officials may need to develop a vaccine.

The worst cases “are unmistakab­le,” he said. “They are paralyzed children that are not moving, and they don’t get better.”

Several states have reported cases of AFM this year. The Maryland Department of Health has confirmed six cases; the Minnesota Department of Health has confirmed seven, all in children under 10.

Jayne Griffith, an epidemiolo­gist at the Minnesota Department of Health, said the afflicted typically develop the disease following a respirator­y or stomach illness.

Messonnier said other common cold viruses also have been detected in some cases.

“There’s sort of a long list of other agents that we have found in one or two,” Messonnier said. “But if you are having the peaks of disease every late summer and early fall, you would think we are finding a single agent. That is what we are not finding.”

 ?? KARE-TV, MINNEAPOLI­S-ST. PAUL ?? Quinton Hill, 7, from Lakeville, Minn., is one of several children in the state diagnosed with acute flaccid myelitis.
KARE-TV, MINNEAPOLI­S-ST. PAUL Quinton Hill, 7, from Lakeville, Minn., is one of several children in the state diagnosed with acute flaccid myelitis.

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