Colts (4-8-1) at Vikings (10-3)
TV: 1 p.m. ET Saturday, NFL Network
Tipico Sportsbook line: Vikings by 4
Preview: The Vikings defense has allowed 400 yards in each of the last five games, but Falcons QB Matt Ryan has been erratic, throwing four interceptions in his last two games.
Ravens (9-4) at Browns (5-8)
TV: 4:30 p.m. ET Saturday, NFL Network
Tipico Sportsbook line:
Browns by 3
Preview: The Browns almost beat the Ravens on the road earlier in the season, but with Ravens QB Lamar Jackson out, Cleveland can pull off a win.
Dolphins (8-5) at Bills (10-3)
TV: 8:15 p.m. ET Saturday, NFL Network
Tipico Sportsbook line:
Bills by 7
Preview: The Bills will be motivated after a Week 3 loss to the Dolphins in which QB Josh Allen was sacked four times.
Falcons (5-8) at Saints (4-9)
TV: 1 p.m. ET Sunday, Fox Tipico Sportsbook line:
Saints by 41⁄2
Preview: Falcons rookie QB Desmond Ridder must make the most of his first career start. The Saints have averaged just 13.2 points per game since Halloween.
Steelers (5-8) at Panthers (5-8)
TV: 1 p.m. ET Sunday, CBS Tipico Sportsbook line:
Panthers by 3
Preview: The Panthers have to run to win, and that rests in large part on their improved offensive line. Interim head coach Steve Wilks has his Panthers humming.
Eagles (12-1) at Bears (3-10)
TV: 1 p.m. ET Sunday, Fox Tipico Sportsbook line:
Eagles by 81⁄2
Preview: The Eagles offense has been rolling, and there will be plenty of opportunities to find success against a struggling Bears pass rush.
Chiefs (10-3) at Texans (1-11-1)
TV: 1 p.m. ET Sunday, CBS Tipico Sportsbook line:
Chiefs by 14
Preview: Houston gave Dallas a scare in Week 14 by using gimmicks, but Kansas City is too polished at this time of year to play down to the Texans’ level.
Cowboys (10-3) at Jaguars (5-8)
TV: 1 p.m. ET Sunday, Fox Tipico Sportsbook line: Cowboys by 41⁄2
Preview: Jaguars QB Trevor Lawrence has 10 touchdown passes and no interceptions in his last five games, but the Cowboys have a ferocious pass rush. Their RBs can take advantage of Jacksonville’s poor run defense.
Lions (6-7) at Jets (7-6)
TV: 1 p.m. ET Sunday, CBS Tipico Sportsbook line:
Jets by 1⁄2
Preview: At home in the cold, the Jets should have a slight edge, though the Lions have been playing much better of late.
Cardinals (4-9) at Broncos (3-10)
TV: 4:05 p.m. ET Sunday, Fox Tipico Sportsbook line: Broncos by 3
Preview: Cardinals QB Kyler Murray (torn ACL) is out for the season and the Broncos’ Russell Wilson was limited in practice after being hurt last week against the Chiefs. Denver has an edge at home in an expected matchup of backup QBs.
Patriots (7-6) at Raiders (5-8)
TV: 4:05 p.m. ET Sunday, Fox Tipico Sportsbook line:
Raiders by 1⁄2
Preview: The defense has led the way as the Patriots got into a playoff spot. It must stop leagueleading rusher Josh Jacobs, who’s rested after a bye week.
Titans (7-6) at Chargers (7-6)
TV: 4:25 p.m. ET Sunday, CBS Tipico Sportsbook line: Chargers by 3
Preview: Los Angeles hasn’t been good against the run, so minimizing Derrick Henry will be its only shot. He’ll be too much for the Chargers.
Bengals (9-4) at Bucs (6-7)
TV: 4:25 p.m. ET Sunday, CBS Tipico Sportsbook line: Bengals by 31⁄2
Preview: Tampa Bay’s defense has been ravaged by injuries, which should mean room for QB Joe Burrow and WRs Ja’Marr Chase and Tee Higgins to make plays.
Giants (7-5-1) at Commanders (7-5-1)
TV: 8:20 p.m. ET Sunday, NBC, Universo
Tipico Sportsbook line: Commanders by 41⁄2
Preview: The Giants hit Taylor Heinicke 10 times and sacked him five times in Week 13, but when he had time, the Commanders did what they wanted in the passing game.
Rams (4-9) at Packers (5-8)
TV: 8:15 p.m. ET Sunday, ESPN, ABC, ESPN2, ESPN Deportes Tipico Sportsbook line: P ackers by 7
Preview: The Rams haven’t won a road game since September. The Packers, coming out of the bye, can score enough to get by the defending Super Bowl champs.