HOW THEY MATCH UP

SAN FRANCISCO (15-4) AT PHILADELPHIA (15-3)

THE LINE

■ Eagles by 2½ SERIES RECORD

■ 49ers lead 19-14-1.

LAST MEETING

■ 49ers defeated the Eagles 17-11 on Sept. 9, 2021, in Philadelphia.

LAST WEEK

■ 49ers defeated Cowboys 19-12; Eagles beat Giants 38-7. KEY MATCHUPS

■ Eagles OTs Jordan Mailata and Lane Johnson vs. 49ers DE Nick Bosa. LT Mailata is part of a talented Philadelphia offensive line that had three players, RT Johnson, C Jason Kelce and LG Landon Dickerson, make the Pro Bowl. Mailata was selected as an alternate for the Pro Bowl, and the 6-foot-8, 365-pound Australian native and former rugby player will get the biggest test of his career against Bosa, who led the NFL with 18½ sacks and is a finalist for Defensive Player of the Year. When San Francisco has the ball, Pro Bowl LT Trent Williams will face a similar challenge against Eagles edge rusher Haason Reddick, who added to his regular-season total of 16 sacks with 1½ sacks against Giants.

KEY INJURIES

Eagles CB Avonte Maddox (toe) returned to practice this week. He has not played since getting injured Dec. 24 against Dallas. Johnson, who is playing with a torn abductor, also was limited in practice last week. WR A.J. Brown was held to just three catches for 22 yards against the Giants and appeared frustrated in the second half. Coach Nick Sirianni confirmed Monday that Brown was dealing with an undisclosed injury, but he was not listed on the injury report this week, indicating he will be healthy and ready today. For the 49ers, WR Deebo Samuel (ankle) and backup RB Elijah Mitchell (groin) did not practice Wednesday. Backup CB Ambry Thomas (ankle) and backup DE Charles Omenihu (oblique) were limited in practice. All four players are likely to play today, coach Kyle Shanahan said. Omenihu will play if healthy in spite of being arrested Monday after a domestic violence allegation. Shanahan said the organization will let the legal process play out.

STATS AND STUFF

The Eagles have a league-high eight Pro Bowl selections: QB Jalen Hurts, Brown, Johnson, Kelce, Dickerson, Reddick, RB Miles Sanders and CB Darius Slay. The 49ers have six: Bosa, Williams, S Talanoa Hufanga, LB Fred Warner, FB Kyle Juszczyk and TE George Kittle . ... San Francisco has won 12 straight games overall . ... The 49ers defense limited opponents to a leaguebest 300.6 yards during the regular season and held the Cowboys to 282 yards last week. Defensive coordinator DeMeco Ryans, a former linebacker who played for the Eagles for four of his 10 seasons, is a top head coaching candidate. Ryans already has interviewed for head coaching openings in Houston and Denver and is drawing interest from the Colts, Cardinals and Panthers . ... The 49ers are playing in their second straight NFC title game and third in four years. They last played in the Super Bowl on Feb. 2, 2020, losing 31-20 to the Chiefs . ... San Francisco K Robbie Gould has made all 29 career field-goal attempts in the postseason, including 4-for4 against Dallas last week. ... Hurts and 49ers QB Brock Purdy met once previously, though it was in college. On Nov. 9, 2019, Hurts led Oklahoma to a 42-41 win over Purdy and Iowa State. In that game, Hurts threw for 273 yards and three TDs and rushed for 88 yards and two scores. Purdy matched him, tossing five TDs, but threw an interception with 24 seconds left on a 2-point conversion try, sealing the win for the Sooners.