The Denver Post

HAIR GENES MIGHT SHED LIGHT ON GRAYING, BALDING

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Scientists have found a host of genes associated with human hair growth— including, for the very first time, a gene they believe contribute­s to hair going gray.

The study, published Tuesday in Nature Communicat­ions, also plucks out genes associated with monobrows, eyebrow and beard bushiness, hair color and shape, and balding.

“It was only possible because we analyzed a diverse melting pot of people, which hasn’t been done before on this scale,” study author Kaustubh Adhikari of University College London said in a statement. Adhikari and his colleagues sifted through the genetic data of more than 6,300 men and women from across Latin America, covering a wide range of ethnic background­s. By taking note of their intrinsic hair traits and comparing them to their genomes, they were able to weed out which genes were correlated to the same traits.

The gene IRF4, which had been known to influence hair color by helping to make and store melanin — the substance that gives our eyes, skin, and hair their distinct shades— is now pinned to graying hair, too. Hair goes gray with age when pigment cells stop producing melanin. IRF4 doesn’t cause gray hair, but its presence seems correlated with an earlier loss of hair color.

Scientists don’t yet know the mechanism by which these genes influence hair type. But if they can figure that out, they could theoretica­lly design hair treatments that stopped those processes in their tracks.

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