Baltimore (2-0) and Kansas City (2-0): Baltimore has been among the most-balanced teams in the league, ranking second in overall defense and first in yards gained. Boosting the Ravens to the top in yards gained is an average of 541.5 yards, led by Lamar Jackson’s superb passing and running. KC is first in passing offense, but this is a major test.
Pittsburgh (0-2) at San Francisco (2-0): The Steelers are looking to avoid only their second 0-3 start since 2000 with Mason Rudolph making his first career start in place of injured quarterback Ben Roethlisberger. Meanwhile, the 49ers seek their first 3-0 start since 1998 and seventh since the 1970 merger.
New Orleans (1-1) at Seattle (2-0): New Orleans coach Sean Payton will play both Teddy Bridgewater and versatile Taysom Hill at QB. The Seahawks are 15-0 in September home games under Pete Carroll. Russell Wilson is 6-0 with 12 touchdowns and two picks in his past six home contests.
Houston (1-1) at Los Angeles Chargers (1-1): The Texans have forced a turnover in 15 straight games, the longest active streak in the NFL. Chargers RB Austin Ekeler leads the NFL with four TDs and his 287 yards from scrimmage are the most by a Chargers running back through the first two games in franchise history.
Los Angeles Rams (2-0) at Cleveland (1-1): Rams coach Sean McKay’s 26-8 record is the best through 34 games for any coach hired in the 21st century. Cleveland’s Myles Garrett leads the league with five sacks in two games.
Oakland (1-1) at Minnesota (1-1): Derek Carr broke Ken Stabler’s Raiders record for career passing yards last week. He has 19,196. But Minnesota’s defense will be a challenge. The Vikings seek the franchise’s 500th victory.
Cincinnati (0-2) at Buffalo (2-0): The Bengals have won four of the past five meetings, including past two on the road, dating to 2011 since snapping a 10-game skid spanning 1989-2010. The Bills have scored nine touchdowns in their past nine drives inside opponents’ 20-yard line dating to last season.
Atlanta (1-1) at Indianapolis (1-1): The Colts’ defense is second in the league with eight sacks and hasn’t allowed a 100yard rusher in 20 consecutive regular-season games, second-longest streak behind New Orleans (24). Falcons star Julio Jones has three TDs this season and at least one in a league-high six consecutive games.
Detroit (1-0-1) at Philadelphia (1-1): Lions QB Matthew Stafford feasts on the Eagles’ defense. Stafford has thrown eight TDs without an interception in two meetings. Philly is very banged up on both sides of the ball.
Denver (0-2) at Green Bay (2-0): Green Bay is 5-0-1 against the Broncos at home. The Broncos would become the 14th team to reach 500 overall wins with a victory.
New York Jets (0-2) at New England (2-0): Third-string QB Luke Falk vs. six-time Super Bowl winner Tom Brady, both the 199th pick in their drafts and both getting their opportunity through injury.
Miami (0-2) at Dallas (2-0): There is more speculation on the Dolphins going 0-16 than there is on who will be left on the roster by the end of the schedule. Dallas, on the other hand, is looking like a true championship contender.
New York Giants (0-2) at Tampa Bay (2-0): All that positive talk about Daniel Jones’ preseason performances had Giants fans salivating. Now they get to see the sixth overall draft pick behind center in games that count. Bucs RB Peyton Barber is coming off rushing for 82 yards and a touchdown in last week’s win at Carolina.
Carolina (0-2) at Arizona (0-1-1): Standout LB Luke Kuechly leads the Panthers’ defense with 25 tackles. Cardinals WR Larry Fitzgerald needs 10 catches to pass Hall of Fame TE Tony Gonzalez for second on the NFL’s all-time receptions list.