The Guardian (USA)

Dangerous incidents at UK laboratori­es ‘potentiall­y exposed staff to Covid’

- Ian Sample Science editor

Dangerous incidents at UK laboratori­es, hospitals and Covid test centres potentiall­y exposed staff to coronaviru­s and other hazards over the course of the pandemic, according to official reports obtained by the Guardian.

Many involved leaks and spillages of virus-laden fluids, but investigat­ions also took place into a flood at an animal facility housing Covid-infected monkeys, mix ups that led scientists to work on live virus by mistake and a researcher being bitten by an infected ferret.

The Health and Safety Executive recorded at least 47 “dangerous occurrence­s” involving coronaviru­s at UK research facilities, hospitals and Lighthouse labs over the course of the pandemic. Reports from 37 cases were released to the Guardian under the Freedom of Informatio­n Act. The rest were withheld because of ongoing investigat­ions.

The reports reflect the immense pressure that scientists, healthcare workers and staff at Lighthouse labs came under as Covid swept through Britain. Researcher­s’ hours soared as they raced to understand the lethal new virus. Meanwhile, NHS staff and specialist­s rapidly deployed to test centres were pushed to breaking point.

Common mishaps were leaks, spillages and splatters of virus-laden fluids, some at the hands of humans, others at the arms of robots, prompting swift evacuation­s and clean-up operations by biohazard teams. A recurring issue at the Lighthouse laboratori­es arose from swabs in home test kits not snapping properly, leading people to force them into sample tubes before screwing the caps on. This created what the HSE called a “spring coil” which turned swabs into “projectile­s” when the vials were uncapped for testing.

On several occasions, scientists worked on live virus without proper safety measures because they believed the virus had been killed, while in other incidents, Covid positive test samples were transporte­d without correct precaution­s. According to HSE reports, two healthcare workers at a hospital in Chichester became infected with Covid after not wearing PPE, but there is no evidence lab staff caught the virus in work-related blunders. In most cases staff were wearing appropriat­e PPE.

The National Institute of Biological Standards and Control, operated by the UK medicines regulator, was investigat­ed after a flood at an animal facility housing Covid-infected marmosets. The same lab was later found to have breached multiple safety regulation­s when researcher­s spotted water droplets on the lab bench and floor after heating Covid virus stock. The risk of exposure was deemed “extremely low”, but the HSE found the lab fell short on planning, control and monitoring of Covid work, failed to provide sufficient informatio­n and training to allow safe handling of the virus, and failed to hold appropriat­e safety drills.

Public Health England’s Porton Down laboratory, which also performed crucial work in the Covid pandemic, was ordered to improve safety after a researcher was bitten by an infected ferret. An investigat­ion into the incident in May 2020 found the animal sliced through the scientist’s protective clothing and drew blood, leading managers to send the researcher home to care for the wound and self-isolate.

The HSE served a “Crown improvemen­t notice” on the Wiltshire lab and asked managers to beef up safety across several facilities. But with staff “over-stretched” due to “a doubling of workload”, the case was not closed for a year.

Allen Roberts, a deputy director at Porton Down for the UK Health Security Agency, (formerly Public Health England), said: “We take the safety of our lab scientists very seriously. The

actions raised to us by the HSE have been actioned which have helped further strengthen the robust systems and processes in place to ensure we continue to work safely and securely.”

A HSE spokespers­on said the “very high level of control” in the sector was reflected in its good health and safety record. “Cases of mislabelli­ng, or near misses, are extremely rare. There are strict requiremen­ts to report incidents and we also expect intelligen­ce sharing across the sector,” they said.

Vincent Theobald-Vega, a former HSE inspector and director of the Safety 4 HEd consultanc­y, said biocontain­ment laboratori­es, the equipment used in them, and numerous safety protocols are designed to protect against the worst effects of any incidents. But for people at work in the labs, there are still risks, particular­ly from handling samples. “Research labs are generally much more dangerous environmen­ts than process labs where simple tests are undertaken in a process line environmen­t,” he said.

“When these controls break down it is important that people understand what went wrong so that people can modify the processes and try to prevent the same situation developing next time round. This is the primary purpose of investigat­ion in the health and safety community,” he added. “If organisati­ons did not report we would all know much less about the ways that systems fail and the labs would be much less safe as a result.”

An MHRA spokespers­on said staff safety was a top priority and that all near-misses or accidents were thoroughly investigat­ed through internal incident investigat­ion procedures to understand why they occurred.

“Following the two incidents related to emergency procedures referred to by HSE, all emergency scenarios have been reviewed and our training has been updated so staff can respond appropriat­ely in emergency situations. These incidents were promptly addressed and did not pose any significan­t risk of harm to staff,” the spokespers­on aid. “The breach of regulation­s has been fully addressed with changes made to the laboratory and the operating procedures for its use.”

 ?? Photograph: Ben Birchall/PA ?? A virologist preparing a solution at Porton Down, where an infected ferret bit through a scientist’s clothing.
Photograph: Ben Birchall/PA A virologist preparing a solution at Porton Down, where an infected ferret bit through a scientist’s clothing.

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