The Guardian (USA)

We’re all living longer. Instead of struggling to stay young, why not learn to age well?

- Devi Sridhar

In the words of Taylor Swift, I might be “feeling 22” but the reality is that my 39th birthday approaches and with that the slow creep to 40: official midlife territory. The desire to stay young feels like a universal pursuit, whether you are Swift, Madonna or Jeff Bezos. Indeed, it is an obsession that transcends the centuries: in 1513, explorer Juan Ponce de León discovered Florida while searching for the fountain of youth and eternal life.

Fast forward just more than 500 years and American tech centimilli­onaire Bryan Johnson is on his own voyage of discovery. Johnson reportedly spends $2m (£1.6m) a year on an intensive regime designed to reduce his biological age from 45 to 18. He recently made headlines for injecting himself with his 17-year-old son’s plasma, after studies in mice showed young blood can rejuvenate old tissue.

In these experiment­s, two mice (one old and one young) were stitched together to share a circulator­y system. Within five weeks, the blood from the younger mouse had restored muscle and liver cells – and enhanced growth of brain cells – in the older one. On the other hand, the young mice who were exposed to older blood had reduced growth. The experiment­s were not without risk. In a 1956 study that joined 69 pairs of rats, scientists noted that if two rats were not adjusted to each other, one would chew the head of the other until it was destroyed. In addition, 11 pairs died within one to two weeks of conjoining, probably due to tissue rejection.

So why would a multimilli­onaire want to be infused with his son’s blood based on such a rudimentar­y experiment? Johnson’s quest is indicative of our singular obsession as a society with looking younger and living longer in the face of an ever-elusive anti-ageing “cure”. Demand for anti-ageing elixirs is huge, from widely available skin and hair products, to surgical procedures andless common medical experiment­s, such as Johnson’s plasma transfusio­ns. The anti-ageing market is expected to surpass $119.6bn globally by 2030.

As people live longer across the world and our societies age, there is

 ?? Photograph: Chris Pizzello/Invision/AP ?? ‘The desire to stay young feels like a universal pursuit, whether you are Taylor Swift, Madonna or Jeff Bezos.’ Taylor Swift performing in Los Angeles, 7 August 2023.
Photograph: Chris Pizzello/Invision/AP ‘The desire to stay young feels like a universal pursuit, whether you are Taylor Swift, Madonna or Jeff Bezos.’ Taylor Swift performing in Los Angeles, 7 August 2023.

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