Indianapolis (6-6) at Houston (9-3): Should Houston get by the Colts, the schedule has visits to the Jets and Eagles and a home finale against Jacksonville. Why can’t the Texans run the table? New Orleans (10-2) at Tampa Bay (5-7): The Saints take the NFC South with a win or a Carolina loss. Bucs quarterback Jameis Winston has not turned over the ball since regaining the starting job two weeks ago.
Los Angeles Rams (11-1) at Chicago (8-4): This is an intriguing matchup, LA’s second-ranked offense against Chicago’s No. 4 defense. Chicago’s defense leads the NFL with 21 interceptions and will test Jared Goff.
New England (9-3) at Miami (6-6): A Patriots win – this is one place they don’t like, having lost four of the past five at Miami – means yet another AFC East crown, 10 in a row. Miami has been outgained by 1,168 yards but is in wild-card contention.
Baltimore (7-5) at Kansas City (10-2): Beating the high-powered Chiefs at Arrowhead calls for a monstrous defensive showing, and Baltimore has the top-ranked D and also a clock-killing run game. Still, Kansas City is 5-0 at home and leads the league at 37 points per game.
Cincinnati (5-7) at Los Angeles Chargers (9-3): With Cincinnati in a rugged, injury-caused slump, LA could romp Sunday. Philip Rivers has thrown two or more TDs in each of his first 12 games, tied for the third-longest streak to begin a season in NFL history. Pittsburgh (7-4-1) at Oakland (2-10): The Steelers are 3-8 all time in Oakland. Still, unless they hand things to the Raiders, they should win even without standout RB James Conner (ankle). Philadelphia (6-6) at Dallas (7-5): Dallas has won four straight and comes off an impressive victory against the Saints. Eagles TE Zach Ertz has already established a single-season franchise record with 93 receptions. New York Giants (4-8) at Washington (6-6): Mark Sanchez is the Washington starter with both Alex Smith and Colt McCoy out with broken legs. New York, which lost star safety Landon Collins (shoulder) for the season, has won three of four since its bye.
Atlanta (4-8) at Green Bay (4-7-1): Most interesting story line is Joe Philbin taking over as Packers coach and calling plays for the first time in his pro career. The Atlanta defense is 31st against third downs (51 percent). Denver (6-6) at San Francisco (2-10): The Broncos have awakened with three consecutive victories, but lost top wideout Emmanuel Sanders with a torn Achilles tendon. San Francisco’s five takeaways are the fewest through 12 games since at least 1940. Carolina (6-6) at Cleveland (4-7-1): A four-game slide has seriously endangered the Panthers’ playoff chances. Their passing game has struggled and Cam Newton has a sore right shoulder. But they’re averaging 140.8 rushing yards per game. The Browns lead the AFC with 27 takeaways.
New York Jets (3-9) at Buffalo (4-8): It looks as if Sam Darnold is recovered from his strained right foot, setting up a matchup with fellow firstround selection Josh Allen.
Detroit (4-8) at Arizona (3-9): The Lions have lost eight straight at Arizona. Cardinals WR Larry Fitzgerald needs one catch to move ahead of Jerry Rice for the most receptions for one team in NFL history.
Defensive end J.J. Watt and Houston can nearly lock up the AFC South with a win against Indianapolis.