Jacksonville (5-10) at Houston (10-5): Houston leads and takes the AFC South by beating the struggling Jaguars. A Texans loss gives the winner of the Colts-Titans primetime game the crown, dropping Houston into a wild card.
Indianapolis (9-6) at Tennessee (9-6): Advantage Andrew Luck in this rivalry: he is 10-0 in his career starts vs. the Titans. He could become the only player since 1970 with an 11-0 mark against one team. Titans QB Marcus Mariota is questionable to start as he recovers from a stinger that knocked him out of the last game against Washington.
Cincinnati (6-9) at Pittsburgh (8-6-1): Pittsburgh has won 10 of the past 11 meetings with Bengals, and need a win and a Browns loss to reach the playoffs.
Cleveland (7-7-1) at Baltimore (9-6): If the Ravens beat Cleveland, they take the AFC North. Cleveland is looking to finish with a winning record after going 0-16 in 2017. Philadelphia (8-7) at Washington (7-8): If Philadelphia wins and Minnesota fails, the Eagles get a chance to defend their Super Bowl crown – with Nick Foles again at quarterback.
Chicago (11-4) at Minnesota (8-6-1): A Vikings a loss ruins their season one year after making the NFC title game. But the Bears have lost six straight games in Minnesota and doing so again likely sends the Vikings to Soldier Field the following week.
Oakland (4-11) at Kansas City (11-4): The Chiefs can clinch the AFC West and No. 1 seed with a win, and they have handled Oakland in seven of the past eight meetings. But a loss and Chargers win drops Kansas City to fifth seed.
Los Angeles Chargers (11-4) at Denver (6-9): The playoff-bound Chargers have won five straight on the road, tied for the franchise’s longest since the merger. But QB Philip Rivers is 12-15 vs. Denver, including the playoffs.
San Francisco (4-11) at Los Angeles Rams (12-3): A win or tie gives the Rams a wild-card round bye, but star running back Todd Gurley won’t play because of knee issues.
Carolina (6-9) at New
Orleans (13-2): With nothing to accomplish as a guaranteed top NFC seed, the Saints could rest people while seeking the franchise’s first 14-win season. Carolina goes with rookie quarterback Kyle Allen for his first career start.
New York Jets (4-11) at New England (10-5): A victory would clinch New England’s 13th first-round bye in the AFC playoffs since 2001. The Patriots would also earn a firstround bye with losses by Baltimore, Houston and Tennessee. New England also can clinch home-field advantage with a win and losses by Kansas City and the Chargers.
Arizona (3-12) at Seattle (9-6): The Seahawks’ top rushing game has landed them an NFC wild card. A Cardinals loss would lock in the No. 1 pick in next April’s draft.
Dallas (9-6) at New York Giants (5-10): The Cowboys, the NFC’s fourth seed, have won six of their past seven overall. Ezekiel Elliott leads the NFL with 1,434 yards rushing, but how much action will he see? Giants RB Saquon Barkley ranks third in rushing (1,198 yards). Miami (7-8) at Buffalo (5-10): The Dolphins have lost five of the past six games at Buffalo. Bills RB LeSean McCoy’s 488 yards rushing are 149 shy of his career low set in his rookie season with the 2009 Eagles.
Atlanta (6-9) at Tampa Bay (5-10): The Falcons have won four straight against their NFC South rival. WR Julio Jones leads the NFL with 1,539 receiving yards and has 104 catches.
Detroit (5-10) at Green Bay (6-8-1): Detroit will try to win consecutive games at Lambeau Field for the first time since 1990-91.
The Chargers and quarterback Philip Rivers enter the regular-season finale as the AFC’s No. 5 seed, with a chance to still win the West.