Will U.S. go for combo heart pill?

A cheap, daily pill that combines four drugs has been tested for the first time in the United States to see if it works as well among lowincome Americans as it has in other countries to treat conditions leading to heart attacks and strokes.

Experts said the study may draw U.S. interest to a strategy that has been seen as useful only in places with limited access to medical care.

The pill contained low doses of three blood pressure drugs and a cholesterol drug.

About 300 people, ages 45 to 75, from a community health center in Mobile, Ala., took part. Half were assigned to take the combo pill. The others continued their usual care.

After a year, the polypill patients had lowered their blood pressure and LDL, or bad cholesterol, by more than the others and by amounts doctors find meaningful.

The study didn’t last long enough to measure heart attacks or strokes. A fiveyear study of a different polypill, in 6,800 people in Iran, found it lowered the danger of heart attack, stroke or heart failure by a third.

Polypills aren’t yet available in the United States. Many U.S. doctors have seen little need, preferring to tailor medications individually, said Dr. Salim Yusuf of McMaster University in Canada, who leads another polypill study expected to finish next year.

But doctors often fail to customize medications because they don’t have time and patients dislike return visits.

“That just doesn’t happen in practice,” Yusuf said.

The research , paid for by the American Heart Association and the National Institutes of Health, was published Wednesday by the New England Journal of Medicine.