Thanksgiving NFL Matchups

BUFFALO (7-3) AT DETROIT (4-6)

KICKOFF: 12:30 p.m., CBS.

FANDUEL SPORTSBOOK NFL LINE: Bills by 9½

AGAINST THE SPREAD: Buffalo 5-5; Detroit 6-3-1

SERIES RECORD: Bills lead 6-4-1.

LAST MEETING: Bills beat Lions 14-13 on Dec. 16, 2018, at Orchard Park, N.Y.

LAST WEEK: Bills beat Browns 31-23; Lions beat Giants 31-18 PLAYERS TO WATCH: Bills WR Stefon Diggs. The Browns held Diggs without a catch until he scored the go-ahead TD on a 5-yard reception with 14 seconds left in the first half. He finished with a season-low 48 yards receiving on four catches. ... Lions RB Jamaal Williams had a career-high three touchdowns against the Giants. Williams joined Shaun Alexander, LaDainian Tomlinson and Priest Holmes as the only players since 2000 to have more than one rushing TD in at least five of a team’s first 10 games in a season.

KEY MATCHUP: Buffalo’s running game against Detroit’s defense. Bills RB Devin Singletary ran for a season-high 86 yards, the same total rookie RB James Cook had for his best game on the ground in the win over Cleveland. That production took pressure off QB Josh Allen. The Lions have been shaky against the run, but they did limit Giants RB Saquon Barkley to a season-low 22 yards on 15 carries.

KEY INJURIES: Bills DE Greg Rousseau (ankle) will miss his third straight game and LB Tremaine Edmunds (groin) was ruled out for Thursday . ... DE A.J. Epenesa (ankle) is doubtful after he was hurt Sunday and C Mitch Morse (elbow, ankle) is questionable . ... Lions will be without perhaps their best player on defense, CB Jeff Okudah, and starting guard Jonah Jackson because of the concussion protocol. Starting guard Evan Brown (ankle) did not practice Monday and Tuesday, another setback for an OL that lost starting OG Halapoulivaati Vaitai to back surgery in September . ... DEs Charles Harris (groin) and Josh Paschal (knee) did not play against the Giants, and were held out of practice early in the week.

STATS AND STUFF: The Bills return to Detroit for a second straight game after the NFL moved their game against Cleveland to Ford Field after a massive snowstorm that dumped as much as 7 feet of snow across Western New York . ... The Bills will be the third NFL team to play two games in five or fewer days on the road in the same stadium. The 2020 Patriots did it at SoFi Stadium and the 1932 Porsmouth Spartans did it in Thompson Stadium.