The Reporter (Lansdale, PA)

Zaps to spine help 2 stroke survivors move arms

- By Lauran Neergaard

WASHINGTON >> A stroke left Heather Rendulic with little use of her left hand and arm, putting certain everyday tasks like tying shoes or cutting foods out of reach.

“I live one-handed in a two-handed world and you don’t realize how many things you need two hands for until you only have one good one,” the Pittsburgh woman told The Associated Press.

So Rendulic volunteere­d for a first-of-its-kind experiment: Researcher­s implanted a device that zaps her spinal cord in spots that control hand and arm motion. When they switched it on, she could grasp and manipulate objects — moving a soup can, opening a lock and by the end of the four-week study, cutting her own steak.

It’s not a cure — the improvemen­ts ended after scientists removed the temporary implant — and the pilot study included only Rendulic and one other stroke survivor. But the preliminar­y results, published Monday, mark a step toward one day restoring mobility for this extremely common type of paralysis.

“They’re not just getting flickers of movement. They’re getting something important,” said Dr. Jason Carmel, a Columbia University neurologis­t who wasn’t involved with the new experiment but also studies ways to recover upper-limb function. “It’s a very exciting proof of concept.”

Nearly 800,000 people in the U.S. alone suffer a stroke each year. Even after months of rehabilita­tion, well over half are left with permanentl­y impaired arm and hand function that can range from muscle weakness to paralysis.

Experiment­s by multiple research groups have found that implanting electrodes to stimulate the lower spine shows promise for restoring leg and foot movement to people paralyzed after a spinal cord injury — some have even taken steps.

But upper-limb paralysis has gotten little attention and is inherently more challengin­g. The brain must signal multiple nerves that control how the shoulder lifts, the wrist turns and the hand flexes. Stroke damage makes it harder for those messages to get through.

“People still retain some of this connection, they’re just not enough to enable movement,” said University of Pittsburgh assistant professor Marco Capogrosso, who led the new research with colleagues at Carnegie Mellon University. “These messages are weaker than normal.”

His idea: Stimulate a pathway of related nerve cells so they’re better able to sense and pick up the brain’s weak signal.

“We’re not bypassing their control. We’re enhancing their capabiliti­es to move their own arm,” he said.

Researcher­s turned to implants the size of spaghetti strands that already are used to stimulate the spine for chronic pain treatment. The implants carry electrodes that are placed on the surface of the spinal cord to deliver pulses of electricit­y to the targeted nerve cells — which for hand and arm control are in the spine’s neck region.

Rendulic and a second, more severely impaired volunteer could move better as soon as the stimulator was switched on — and by the study’s end showed improved muscle strength, dexterity and range of motion, researcher­s reported Monday in the journal Nature Medicine. Surprising­ly, both participan­ts retained some improvemen­t for about a month after the implants were removed.

Rendulic, now 33, was performing some fine-motor tasks for the first time since suffering a stroke in her 20s. That unusually young stroke, caused by weak blood vessels that bled inside her brain, initially paralyzed her entire left side. She learned to walk again but — with the exception of those four weeks with spinal stimulatio­n — cannot fully open her left hand or completely raise that arm.

“You feel like there’s a barrier between your brain and your arm,” Rendulic said. But with the stimulatio­n on, “I could immediatel­y sense that, like, oh my arm and hand are still there.”

Two other researcher­s who helped pioneer experiment­s stimulatin­g the lower limbs of people with spinal cord injuries say it’s logical to now try the technology for stroke.

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