The Signal

Gallstones the result of hard bile deposits

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Dear Doctors: I had stabs of pain in the upper right side of my abdomen one day, so I did a telehealth session. The nurse said it might be gallstones and to see my doctor if it repeats. So far, it hasn’t happened again. What are gallstones? How do you get them, and what is the treatment?

Dear Reader: When talking about gallstones, we must also talk about the gallbladde­r. It’s a hollow, flexible organ that sits in the upper right of the abdomen, just below the liver and next to the pancreas.

The gallbladde­r stores a digestive fluid called bile, which the liver produces. Bile breaks down fatty foods into smaller components so they can be readily absorbed and used by the body. Bile also plays an important role in the eliminatio­n of certain waste products, including bilirubin, excess cholestero­l and hemoglobin from aging red blood cells.

The gallbladde­r looks a bit like a deflated balloon when it is empty. Filled with bile, it becomes roughly the shape and size of a small pear. When someone eats foods that contain fat, which require bile for digestion, the gallbladde­r contracts. This forces the thick, sticky fluid into tiny tubules known as bile ducts. They direct the bile into the small intestine, where the absorption of nutrients takes place.

When someone has gallstones, it means that some of the bile in the gallbladde­r has formed into hard, pebblelike deposits. The most common cause is an overabunda­nce of cholestero­l, along with a correspond­ing deficit of bile salts. These are an important component of bile and aid in dismantlin­g fats.

An estimated 20% of adults older than 65 years of age have gallstones. In most cases, they don’t cause symptoms, which is known as “silent gallstones.” Since they don’t interfere with the production or dispersal of bile, silent gallstones don’t require treatment.

But when gallstones block the bile ducts, it can cause a gallbladde­r attack. Symptoms include sudden and ongoing pain in the upper right abdomen, as you experience­d, or sometimes in the central area of the abdomen, just below the breastbone. Less often, the pain occurs between the shoulder blades or in the right shoulder. This pain may be accompanie­d by nausea or vomiting. The motion of the gallbladde­r can shift the gallstones, relieve the blockage and end the attack. But an ongoing blockage can result in inflammati­on and infection of the gallbladde­r, as well as of the liver and pancreas.

It’s important to seek medical care if you have a gallbladde­r attack. Risk factors for developing gallstones include being female, being overweight or obese, eating a fatty diet, not getting enough fiber and rapid weight loss.

When gallstones cause ongoing complicati­ons, diagnostic imaging tests may be required. Treatment options include surgery to remove the gallbladde­r or medication­s to dissolve existing gallstones. Unfortunat­ely, these can take months to work, and they aren’t always effective. Medication­s are typically reserved for those who are poor surgical candidates. Meanwhile, because other conditions can cause the pain you described, it’s a good idea to check in with your doctor.

Eve Glazier, M.D., MBA, is an internist and associate professor of medicine at UCLA Health. Elizabeth Ko, M.D., is an internist and assistant professor of medicine at UCLA Health. Send your questions to askthedoct­ors@ mednet.ucla.edu, or write: Ask the Doctors, c/o UCLA Health Sciences Media Relations, 10960 Wilshire Blvd., Suite 1955, Los Angeles, CA, 90024. Owing to the volume of mail, personal replies cannot be provided.

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Drs. KO AND GLAZIER

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