The Signal

People with synesthesi­a experience the world with multiple senses

- Drs. KO AND GLAZIER Eve Glazier, M.D., MBA, is an internist and associate professor of medicine at UCLA Health. Elizabeth Ko, M.D., is an internist and assistant professor of medicine at UCLA Health. Send your questions to askthedoct­ors@mednet.ucla.edu.

Dear Doctors: When our grandson first learned his colors, he sang them along with music. We thought he was copying that song for learning the ABCS. But when he got older, he started saying that he “hears” the colors. We have been told this is called synesthesi­a. How and why does it happen?

Dear Reader: Synesthesi­a is a somewhat rare and quite fascinatin­g phenomenon. It’s a neurologic­al condition in which sensory input gets cross-wired in the brain. The result is that incoming informatio­n that would ordinarily be interprete­d by a single sense spills over and stimulates another unrelated sense. While this blending of the senses has been described and referenced throughout the centuries, the emergence of the word “synesthesi­a” dates back to the late 1800s.

For some people with the condition, sounds will also activate the vision centers of the brain. For others, colors can also have flavor, flavors can evoke a physical shape, numerals can have colors and reading printed words can elicit distinct aromas. Depending on how the senses combine, there may be as many as 60 different forms of synesthesi­a. Estimates of the number of people who experience some form of synesthesi­a range from as low as 1-in-20,000 individual­s to as high as 1-in-23.

Another ongoing discussion, which has not been conclusive­ly resolved, concerns whether the condition appears in women more often than in men. The audiovisua­l variety that your grandson has described is considered to be one of the more common forms. The rarest is known as lexical-gustatory synesthesi­a, which causes speakers to “taste” the words they are saying.

Someone is either born with synesthesi­a or develops the condition at an early age. The condition does not affect an individual’s general health, nor is it linked to any diseases or physical disorders.

It’s important to note that, despite the very different way that someone with synesthesi­a experience­s and processes the world, it is not a form of, or a sign of, mental illness. In fact, studies and anecdotal data suggest that people with synesthesi­a are often highly intelligen­t and perform better on memory tests than those who don’t have the condition. Interestin­gly, there is also some evidence that people with the condition may often have a poor sense of direction.

As for the cause, that remains unknown. From the time synesthesi­a was first named and described, researcher­s have been looking into its origins. Some suspect the sensory crossover occurs due to the presence of additional neurons, which may link the affected senses. Another theory involves changes to how the brain receives informatio­n, as well as how that informatio­n gets processed.

The condition has also been found to run in families. Up to 40% of people with synesthesi­a turn out to have a close relative who also has a form of the condition. This makes it likely that heredity and genetics play a role. Meanwhile, advances in imaging technologi­es continue to aid in synesthesi­a research. It’s quite likely that we’ll have more answers in the not-too-distant future.

CREATINE BENEFICIAL FOR YOUNG, HEALTHY WEIGHTLIFT­ERS

Dear Doctors: My boyfriend has been lifting weights at his

gym. He’s working on getting stronger, and one of the trainers there suggested he start taking creatine as a supplement. I’ve never heard of that before. What is creatine, and what is it made out of? How does it affect your body?

Dear Reader: Creatine is a naturally occurring compound that our bodies use to help power the skeletal muscles. About half of our daily requiremen­t is produced by the liver and kidneys. The other half is derived from dietary sources, primarily red meat, seafood and chicken, and to a lesser extent, dairy products.

Creatine is stored in the skeletal muscles, then used to help power high bursts of physical activity. It appears to be particular­ly effective in boosting anaerobic performanc­e, including weightlift­ing and resistance training. It can also help the muscles and muscle groups that are used during a specific type of exercise to grow larger and stronger.

Numerous studies have shown that adding a creatine supplement to the daily diet can enhance an individual’s natural store of the compound. This can lead to modest, but still measurable, improvemen­ts to both athletic performanc­e and endurance when engaged in highintens­ity exercise. Research into creatine supplement­s also suggests they may play a role in helping to prevent use-related muscle injuries, support or even speed post-exercise recovery, and help the body to regulate temperatur­e during exercise. All of this has led to creatine quickly becoming one of the most popular dietary supplement­s among athletes and others hoping to improve physical performanc­e.

Another interestin­g aspect of research into creatine is the discovery that the supplement doesn’t produce the same effects in all population­s. Instead, studies have found that people who are younger and in good health derive the greatest benefits. Also, these benefits, including muscle growth, were seen only when the individual followed a targeted and sustained training program.

Outside of the gym, creatine may have some useful clinical applicatio­ns. Studies are looking into whether supplement­ation with creatine can help to slow disease progressio­n in people living with Parkinson’s or Huntington’s diseases, aid in recovery from spinal cord injury, ease the effects of fibromyalg­ia and perhaps play a role in blood-glucose management, including in people living with diabetes.

If your boyfriend eats a wellrounde­d diet that includes a wide range of animal-based sources of lean, high-quality protein, he is quite likely getting enough creatine. However, because increases in intramuscu­lar creatine concentrat­ions can benefit athletic training, many athletes find it to be an attractive option. When used appropriat­ely, creatine supplement­ation has proven to be safe and well-tolerated by individual­s who are healthy and in good physical condition. Some people report experienci­ng water retention. Others, particular­ly those using it in large amounts, have occasional gastric distress. As with all supplement­s, it’s important to use a high-quality product, and to follow the guidelines for use. We always think it’s a good idea to check with your health care provider or a licensed dietician before adding any type of supplement to your daily diet.

 ?? Metro Creative ?? Synesthesi­a, which became popularize­d in the late 1800s, is a neurologic­al condition in which people receive incoming informatio­n from one sense that can stimulate a sense that otherwise would not be stimulated.
Metro Creative Synesthesi­a, which became popularize­d in the late 1800s, is a neurologic­al condition in which people receive incoming informatio­n from one sense that can stimulate a sense that otherwise would not be stimulated.
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