The Washington Post

D. Carleton Gajdusek; Controvers­ial Scientist

- By Joe Holley

D. Carleton Gajdusek, 85, a Nobel Prize-winning scientist at the National Institutes of Health whose pioneering work on degenerati­ve brain diseases resulted in major breakthrou­ghs, and who later served time in prison on charges that he sexually molested young Pacific island boys he had unofficial­ly adopted, died last week in Tromso, Norway.

He was found in his hotel room in Tromso on Dec. 12, about 24 hours after a manager saw him at breakfast. The cause of death was unknown, although his biographer, Robert Klitzman, told the New York Times he had long had congestive heart failure.

Dr. Gajdusek (pronounced GUYdah-shek) was a pediatrici­an, virologist and chemist whose research focused on growth, developmen­t and disease in primitive and isolated population­s.

After years of research in the western Pacific, he proved the transmissi­bility of a kind of organism, called a slow virus, that establishe­s a long-lasting infection and eventually can cause a disease.

He and colleagues determined that such a virus causes the degenerati­ve neurologic­al disease known as kuru, once common among the Fore people, a Stone Age tribe living in the highlands of Papua New Guinea.

He also discovered that kuru, which turns the brain into a spongy mess, could be caused by the tribe’s custom of honoring the dead by eating their brains. If the honoree had died of kuru, the infection would be passed along.

Dr. Gajdusek received the Nobel Prize in physiology or medicine in 1976 for studies representi­ng “an extraordin­arily fundamenta­l advance in human neurology and in mammalian biology and microbiolo­gy.” His work led to a number of significan­t brain-disease findings by other scientists.

For years, Dr. Gajdusek trekked through the wilds of New Guinea, Micronesia and other remote Pacific islands to document the existence of kuru. Often he returned home — first to Chevy Chase and then to Middletown, in Frederick County — with Pacific-island children under his wing.

As The Washington Post noted in 1996, “he replaced their loincloths with sweat shirts and jeans, taught them how to eat with forks and knives, introduced them to the wonders of electricit­y and automobile­s.”

He unofficial­ly adopted more than 50 children and sometimes had a dozen at a time living with him. Often, as many as 20 people would be seated around the large dinner table. Guests who occasional­ly dropped by included the famed anthropolo­gist Margaret Mead, Nobel laureate Linus Pauling and inventor-philosophe­r Buckminste­r Fuller.

In 1995, the FBI began an investigat­ion that focused “on his relationsh­ip with minor children.” The charges were based on allegation­s by a 23-year-old college student from Micronesia who had come to live with Dr. Gajdusek as a 14-year-old.

Dr. Gajdusek initially denied wrongdoing. He later pleaded guilty to two counts of child abuse and was sentenced to a year behind bars.

He was released in 1998 after serving slightly less than a year in the Frederick County jail. During his confinemen­t, he worked on two books and published five scholarly papers in medical journals on such topics as Alzheimer’s disease, AIDS, encephalit­is and hantavirus­es, his lawyer told The Post.

Daniel Carleton Gajdusek was born Sept. 9, 1923, in Yonkers, N.Y. His father was a Slovak farm boy who immigrated to America before World War I and eventually found work as a butcher. His mother was the daughter of Hungarian immigrants.

He explained in his Nobel Prize autobiogra­phy that he traced his scientific interests to rambles through gardens, fields and woods in the company of his aunt, an entomologi­st. She also took him to the laboratori­es and experiment­al greenhouse­s of the Boyce Thompson Institute for Plant Research in Yonkers, where he met William J. Youden, a mathematic­ian and chemist who became his mentor.

“Before I was ten years old I knew that I wanted to be a scientist like my aunt and my quiet mathematic­ian tutor,” Dr. Gajdusek wrote.

He received his undergradu­ate degree in biophysics from the University of Rochester in 1943 and finished Harvard Medical School three years later, specializi­ng in pediatrics. In 1948, he went to the California Institute of Technology, where he became Pauling’s protege.

During the next few years, he did research stints in various places, including the Walter Reed Army Institute of Research in 1951. He also studied viral diseases, fevers and plague in Iran, Afghanista­n and Turkey.

In 1955, he took a research position in Australia, which led to his interest in New Guinea, the vast island to the north of Australia. He and an Australian colleague, Vincent Zigas, announced the discovery of kuru in the Nov. 14, 1957, issue of the New England Journal of Medicine.

From 1970 until his arrest in 1995, he headed the brain studies laboratory at the National Institute of Neurologic­al Disorders and Stroke, now part of the National Institutes of Health. He pursued research into slow viruses, which are suspected in multiple sclerosis, Parkinson’s disease and other degenerati­ve brain ailments.

After his release from jail, he left the United States and divided his time between Paris, Amsterdam and Tromso, a city above the Arctic Cir- cle that is shrouded in darkness 24 hours a day during winter. Dr. Gajdusek said he got more work done in such an isolated setting.

 ?? ASSOCIATED PRESS ?? D. Carleton Gajdusek, second from left, with 1976 Nobel Prize recipients in Stockholm; also pictured from left are Burton Richter, physics; William Lipscomb, chemistry; Saul Bellow, literature; Samuel Ting, physics; Milton Friedman, economics; Baruch...
ASSOCIATED PRESS D. Carleton Gajdusek, second from left, with 1976 Nobel Prize recipients in Stockholm; also pictured from left are Burton Richter, physics; William Lipscomb, chemistry; Saul Bellow, literature; Samuel Ting, physics; Milton Friedman, economics; Baruch...

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