The Washington Post

WHO’S Covax effort to get boost from Moderna

500 million doses extend global access even as supply crunch lingers

- BY EMILY RAUHALA AND ERIN CUNNINGHAM emily.rauhala@washpost.com erin.cunningham@washpost.com

Moderna will supply up to 500 million doses of its coronaviru­s vaccine to a campaign backed by the World Health Organizati­on starting late this year, giving a much-needed boost to a global initiative that has suffered from inequity, funding shortfalls and a severe supply crunch.

The agreement, announced Monday soon after the WHO approved the company’s messenger RNA vaccine for emergency use, comes amid growing calls for both vaccine-makers and wealthy nations to do more to address the vaccinatio­n gap between rich countries and the rest of the world.

Following announceme­nts from New Zealand and France, the United States said last week that it will share up to 60 million doses with other countries under as-yet-unknown terms. On Monday, Sweden said it will give 1 million doses of the Oxford-astrazenec­a vaccine to the WHO’S Covax effort to “help address immediate-term supply delays.”

The news comes as U.S. officials remain split over how to vaccinate the world, with some urging the White House to back an internatio­nal proposal to waive drug company patents for coronaviru­s vaccines.

The Moderna deal is good news for vaccine access but comes relatively late. The two-dose vaccine demonstrat­ed a 94.1 percent efficacy rate in clinical trials, one of the highest of all the vaccines in use. It has also shown high effectiven­ess against new variants, particular­ly the one first detected in Britain.

However, the deal will do little to alleviate short- and medium-term supply concerns. Under the agreement, the company will work with Covax to supply 34 million doses at its “lowest tiered price” by the end of 2021, with the option for 466 million shots available in 2022.

Though such countries as Israel, the United States and Britain are beginning to see the benefits of mass vaccinatio­n campaigns, most others are still trying to secure enough vaccine doses. Researcher­s at Duke University predict that some countries will be waiting until 2023.

Covax aims to distribute up to 2 billion doses this year, with an eye toward reaching 20 percent of the population in participat­ing low- and middle-income countries. To date, it has delivered 49 million doses.

The effort has been hit by the dramatic coronaviru­s surge in India. Covax is heavily reliant on the Oxford-astrazenec­a vaccine, particular­ly doses manufactur­ed by India’s Serum Institute. As India’s coronaviru­s death toll has climbed, exports have all but ceased. Covax knows it needs to diversify its vaccine portfolio, but the limited supply of messenger RNA vaccines and temporary halts on the use of other vaccines have made that tough.

On Monday, Denmark removed the single-dose Johnson & Johnson shot from its vaccinatio­n program to investigat­e reports of rare blood clots, the Associated Press reported, unnerving other countries and renewing questions about Covax’s vaccine portfolio. The country had earlier discontinu­ed the Astrazenec­a shot for the same reason.

In recent months, public health advocates have urged the United States to do more to force Moderna to share its vaccine, which was developed and manufactur­ed with significan­t U.S. government support.

The company also received early funding from the Coalition for Epidemic Preparedne­ss Innovation­s, a foundation that is leading Covax alongside the WHO and Gavi, a vaccine alliance. Accepting the grant, Moderna agreed to uphold “equitable access principles.”

Monday’s agreement brings Moderna closer in line with such competitor­s as Pfizer and AstraZenec­a, which have already delivered doses to Covax.

“This is an important milestone as we work to ensure that people around the world have access to our COVID-19 vaccine,” Moderna chief executive Stéphane Bancel said in a news release.

“We are very pleased to sign this new agreement with Moderna, giving COVAX Facility participan­ts access to yet another highly efficaciou­s vaccine,” Seth Berkley, CEO of Gavi, said in a news release.

“Expanding and having a diverse portfolio has always been a core goal for COVAX, and to remain adaptable in the face of this continuall­y evolving pandemic — including the rising threat posed by new variants,” he continued. “This agreement is a further step in that direction.”

 ?? COLE BURSTON/ASSOCIATED PRESS ?? Workers unload a shipment of Moderna’s coronaviru­s vaccine at a Fedex hub in Toronto on April 28.
COLE BURSTON/ASSOCIATED PRESS Workers unload a shipment of Moderna’s coronaviru­s vaccine at a Fedex hub in Toronto on April 28.

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