The Week (US)

Health scare of the week Medication and depression

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Your medicine cabinet could be making you blue. More than one-third of Americans are now taking medication­s that can cause depression as a side effect, according to a new study. Researcher­s identified about

200 prescripti­on drugs that can cause the mood disorder, including many common medication­s taken by older adults, such as proton-pump inhibitors (PPIs), used to treat acid reflux, and beta blockers for hypertensi­on. The study found that the more of these drugs people take, the greater their risk of depression. About 7 percent of participan­ts taking one such drug were depressed, compared with 15.3 percent of those taking three or more. Many doctors “may not be aware that several commonly prescribed medication­s are associated with an increased risk of this disorder,” study author Mark Olfson, a professor at Columbia University Irving Medical Center, tells Consumer Reports. But other experts note that many people taking these medication­s already suffer from conditions that put them at a raised risk of depression. Up to half of people with chronic pain, for example, also have depression or another mood disorder—because the parts of the brain that process pain also affect mood.

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