The Week (US)

...from the first picture of a black hole to a new gene-editing tool

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cell anemia. The most popular existing gene-editing approach, CRISPR-Cas9, uses “molecular scissors” to locate faulty genetic code, then cuts both strands of the DNA double helix and splices in a new section of code. Though cheap and fast, this process often damages nearby code or inserts the new material in the wrong place. The new technology, known as prime editing, cuts only one strand of the double helix— minimizing the risk of unintended changes. a pioneering brain-controlled bodysuit. The patient, identified only as Thibault, had two implants surgically placed over the parts of his brain that control movement. His brain signals are sent to a nearby computer, which translates them into movement instructio­ns for the exoskeleto­n suit. Though years away from being publicly available, the technology could pave the way for mindcontro­lled wheelchair­s and similar equipment. Thibault said taking his first steps felt like being “the first man on the moon.” test to predict if a patient will develop Alzheimer’s, years before symptoms appear. An internatio­nal team of researcher­s found that people geneticall­y predispose­d to the disorder had distinctly higher levels of neurofilam­ent light chain—a protein found in the brain and spinal cord—seven years before symptoms began, and noticeably faster-growing levels more than 16 years in advance. An early test could help scientists determine whether new Alzheimer’s drugs are effective. Study author Mathias Jucker says the reason there is no effective treatment for the condition is “partly because current therapies start much too late.”

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