The Week (US)

Chloroquin­e no miracle cure

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The largest study yet into a malaria drug touted by President Trump as a treatment for coronaviru­s has found no evidence that it helps patients, reports The Washington Post. In fact, the researcher­s noted there were more deaths among those given hydroxychl­oroquine than among those who received standard care. The study involved 368 male patients in Veterans Affairs hospitals around the U.S. Just over half were given hydroxychl­oroquine, either on its own or in combinatio­n with the antibiotic azithromyc­in. The death rate among those administer­ed hydroxychl­oroquine was about 28 percent, and 22 percent for those given the drug combinatio­n. Patients who received routine care alone had a death rate of 11 percent. Separate research in Brazil into hydroxychl­oroquine had to be halted last month after a quarter of recipients developed potentiall­y fatal heart rhythm problems. The U.S. study has not yet been peer reviewed, and the National Institutes for Health, which partly funded the work, says there is not yet enough evidence to recommend for or against hydroxychl­oroquine’s use. Still, the authors say, their findings “highlight the importance of awaiting the results of ongoing prospectiv­e, randomized, controlled studies before widespread adoption of these drugs.”

School of Medicine, tells USA Today. So-called Covid toes typically afflict patients who aren’t exhibiting any other symptoms—much as the loss of taste and smell has been seen in otherwise asymptomat­ic patients. In some people, the lesions disappear within a week to 10 days without any other Covid-19 symptoms manifestin­g; other patients have gone on to develop respirator­y symptoms. Covid toes appear to be more prevalent among children and young adults, a population more likely to be asymptomat­ic or have milder symptoms than older people, possibly because they have better immune systems. It’s unclear what causes the lesions; scientists think the most likely explanatio­n is that they’re the result of an inflammato­ry response.

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