The Week (US)

Breakthrou­gh infections: What they’re telling us

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With the highly contagious Delta variant sweeping across the U.S., vaccinated Americans feel growing concern about “an apparent rise in so-called breakthrou­gh infections,” said Denise Chow in NBCNews.com. Over 150 vaccinated Fourth of July revelers in Provinceto­wn, Mass., tested positive, the New York Yankees reported “multiple confirmed breakthrou­gh cases,” and infections were reported in a vaccinated White House staffer. Breakthrou­gh cases are indeed rising as overall case counts spike, but health officials say that doesn’t mean vaccines are failing. In fact, they’re performing remarkably well, drasticall­y cutting infection rates and deaths and rendering “the vast majority of breakthrou­gh cases” mild or asymptomat­ic. Severe breakthrou­gh illnesses are “exceedingl­y” rare, said Emily Sohn in NationalGe­ographic.com. As of July 19, the CDC counted just under 6,000 among more than 161 million fully vaccinated Americans—a “rate of less than 0.004 percent.”

Much remains unknown, said Selena SimmonsDuf­fin and Rob Stein in NPR.org. Asymptomat­ic breakthrou­gh infections aren’t usually detected, so we have no idea how widespread they are. Vaccinated people who have been exposed to the infection generally carry a lower viral load in their noses, but the CDC says that in “rare cases,” they can infect others. It’s also unclear whether breakthrou­gh cases can lead to the misery of long Covid, but infectious disease expert Monica Gandhi says that long Covid is linked to a “dysregulat­ed inflammato­ry response” that vaccines should prevent.

To understand breakthrou­gh infections, said Katherine Wu in TheAtlanti­c.com, “think of the human body as a castle” and the immune system as its defenders. The unvaccinat­ed have a “flimsy” line of defense that’s easily breached. The vaccinated have waves of defenders that have been trained to attack a “familiar foe.” Some attackers might still breach the wall, but “their ranks are fewer, weaker, and less damaging,” so Covid feels like the flu or a bad cold, rather than like a lifethreat­ening illness. Still, as Delta spreads, even the vaccinated need to rethink “our personal risk calculus,” said Susan Matthews in Slate.com. Should you go to a bar or indoor stadium or wedding unmasked? Factors influencin­g those decisions should include your health, risk tolerance, and local case counts. All this may feel confusing, but we’re entering a future “where Covid is something that we just have to live with.”

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